Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation

Canine parvovirus (CPV) has been used in cancer control as a drug delivery vehicle or anti-tumor reagent due to its multiple natural advantages. However, potential host cell cycle arrest induced by virus infection may impose a big challenge to CPV associated cancer control as it could prevent host c...

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Autores principales:	Xiaofeng Dai, Xuanhao Zhang, Yujie Miao, Peiyu Han, Jianying Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	canine parvovirus cell cycle arrest egfr virotherapy Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e07ec0f999754017ba3f2089f97d7c61
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spelling	oai:doaj.org-article:e07ec0f999754017ba3f2089f97d7c612021-11-17T14:21:59ZCanine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation2150-55942150-560810.1080/21505594.2020.1814091https://doaj.org/article/e07ec0f999754017ba3f2089f97d7c612020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1814091https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Canine parvovirus (CPV) has been used in cancer control as a drug delivery vehicle or anti-tumor reagent due to its multiple natural advantages. However, potential host cell cycle arrest induced by virus infection may impose a big challenge to CPV associated cancer control as it could prevent host cancer cells from undergoing cell lysis and foster them regain viability once the virotherapy was ceased. To explore CPV-induced cell cycle arrest and the underlying mechanism toward improved virotherapeutic design, we focus on epidermal growth factor receptor (EGFR), a cellular receptor interacting with TfR that mediates CPV-host interactions, and alterations on its tyrosine phosphorylation sites in response to CPV infection. We found that CPV could trigger host G1/S cell cycle arrest via the EGFR (Y1086)/p27 and EGFR (Y1068)/STAT3/cyclin D1 axes, and EGFR inhibitor could not reverse this process. Our results contribute to our understandings on the mechanism of CPV-induced host cellular response and can be used in the onco-therapeutic design utilizing CPV by preventing host cancer cells from entering cell cycle arrest.Xiaofeng DaiXuanhao ZhangYujie MiaoPeiyu HanJianying ZhangTaylor & Francis Grouparticlecanine parvoviruscell cycle arrestegfrvirotherapyInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1203-1214 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine parvovirus cell cycle arrest egfr virotherapy Infectious and parasitic diseases RC109-216
spellingShingle	canine parvovirus cell cycle arrest egfr virotherapy Infectious and parasitic diseases RC109-216 Xiaofeng Dai Xuanhao Zhang Yujie Miao Peiyu Han Jianying Zhang Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation
description	Canine parvovirus (CPV) has been used in cancer control as a drug delivery vehicle or anti-tumor reagent due to its multiple natural advantages. However, potential host cell cycle arrest induced by virus infection may impose a big challenge to CPV associated cancer control as it could prevent host cancer cells from undergoing cell lysis and foster them regain viability once the virotherapy was ceased. To explore CPV-induced cell cycle arrest and the underlying mechanism toward improved virotherapeutic design, we focus on epidermal growth factor receptor (EGFR), a cellular receptor interacting with TfR that mediates CPV-host interactions, and alterations on its tyrosine phosphorylation sites in response to CPV infection. We found that CPV could trigger host G1/S cell cycle arrest via the EGFR (Y1086)/p27 and EGFR (Y1068)/STAT3/cyclin D1 axes, and EGFR inhibitor could not reverse this process. Our results contribute to our understandings on the mechanism of CPV-induced host cellular response and can be used in the onco-therapeutic design utilizing CPV by preventing host cancer cells from entering cell cycle arrest.
format	article
author	Xiaofeng Dai Xuanhao Zhang Yujie Miao Peiyu Han Jianying Zhang
author_facet	Xiaofeng Dai Xuanhao Zhang Yujie Miao Peiyu Han Jianying Zhang
author_sort	Xiaofeng Dai
title	Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation
title_short	Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation
title_full	Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation
title_fullStr	Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation
title_full_unstemmed	Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation
title_sort	canine parvovirus induces g1/s cell cycle arrest that involves egfr tyr1086 phosphorylation
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/e07ec0f999754017ba3f2089f97d7c61
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Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation

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