Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-kB signaling and cytokine production in macro...

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Autores principales:	Antonella Managò, Valentina Audrito, Francesca Mazzola, Leonardo Sorci, Federica Gaudino, Katiuscia Gizzi, Nicoletta Vitale, Danny Incarnato, Gabriele Minazzato, Alice Ianniello, Antonio Varriale, Sabato D’Auria, Giulio Mengozzi, Gianfranco Politano, Salvatore Oliviero, Nadia Raffaelli, Silvia Deaglio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0822e35c48442ffa058cd85cc49059a
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spelling	oai:doaj.org-article:e0822e35c48442ffa058cd85cc49059a2021-12-02T16:57:51ZExtracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation10.1038/s41467-019-12055-22041-1723https://doaj.org/article/e0822e35c48442ffa058cd85cc49059a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12055-2https://doaj.org/toc/2041-1723The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-kB signaling and cytokine production in macrophage via NAD synthesis-independent pathways.Antonella ManagòValentina AudritoFrancesca MazzolaLeonardo SorciFederica GaudinoKatiuscia GizziNicoletta VitaleDanny IncarnatoGabriele MinazzatoAlice IannielloAntonio VarrialeSabato D’AuriaGiulio MengozziGianfranco PolitanoSalvatore OlivieroNadia RaffaelliSilvia DeaglioNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonella Managò Valentina Audrito Francesca Mazzola Leonardo Sorci Federica Gaudino Katiuscia Gizzi Nicoletta Vitale Danny Incarnato Gabriele Minazzato Alice Ianniello Antonio Varriale Sabato D’Auria Giulio Mengozzi Gianfranco Politano Salvatore Oliviero Nadia Raffaelli Silvia Deaglio Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
description	The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-kB signaling and cytokine production in macrophage via NAD synthesis-independent pathways.
format	article
author	Antonella Managò Valentina Audrito Francesca Mazzola Leonardo Sorci Federica Gaudino Katiuscia Gizzi Nicoletta Vitale Danny Incarnato Gabriele Minazzato Alice Ianniello Antonio Varriale Sabato D’Auria Giulio Mengozzi Gianfranco Politano Salvatore Oliviero Nadia Raffaelli Silvia Deaglio
author_facet	Antonella Managò Valentina Audrito Francesca Mazzola Leonardo Sorci Federica Gaudino Katiuscia Gizzi Nicoletta Vitale Danny Incarnato Gabriele Minazzato Alice Ianniello Antonio Varriale Sabato D’Auria Giulio Mengozzi Gianfranco Politano Salvatore Oliviero Nadia Raffaelli Silvia Deaglio
author_sort	Antonella Managò
title	Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
title_short	Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
title_full	Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
title_fullStr	Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
title_full_unstemmed	Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
title_sort	extracellular nicotinate phosphoribosyltransferase binds toll like receptor 4 and mediates inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e0822e35c48442ffa058cd85cc49059a
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Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

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