MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel

A highly sensitive electrochemical sensor was constructed by layering a MWCNT on a glassy carbon electrode in presence of cationic surfactant, cetyltrimethyl ammonium bromide (CTAB). Surface morphology of developed sensor was carried by AFM technique and used for the electrochemical detection of an...

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Autores principales:	Jayant I. Gowda, Rohini M. Hanabaratti, Suresh M. Tuwar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Paclitaxel drug Cationic surfactant Limit of detection Pharmaceutical analysis Calibration curve Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e08471117c164fed90cff08e06cf50a3
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spelling	oai:doaj.org-article:e08471117c164fed90cff08e06cf50a32021-11-22T04:24:42ZMWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel2211-715610.1016/j.rechem.2021.100243https://doaj.org/article/e08471117c164fed90cff08e06cf50a32021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221171562100148Xhttps://doaj.org/toc/2211-7156A highly sensitive electrochemical sensor was constructed by layering a MWCNT on a glassy carbon electrode in presence of cationic surfactant, cetyltrimethyl ammonium bromide (CTAB). Surface morphology of developed sensor was carried by AFM technique and used for the electrochemical detection of an anticancer drug paclitaxel (PAC) in pure and dosage form by cyclic and differential pulse voltammetric techniques. Results showed modified sensor exhibited high specific surface area and its morphology consists of very thick and fine particles of MWCNT in presence of surfactant. Optimized the experimental condition by varying the surfactant concentration, accumulation time, buffer pH and scan rate. With standard pH of 7.0, for different scan rate variation (25 to 300 mV/s) a diffusion controlled surface phenomenon was observed on constructed sensor. Detailed electro-chemical oxidation mechanism was proposed based on the obtained result. MWCNT-CTAB/GCE provided lower detection limit and lower quantification limit of 4.38 × 10−10 M and 1.46 × 10−9 M respectively over the concentration ranges of 10.0 × 10−8 and 12.0 × 10−6 M.The MWCNT-CTAB/GCE was successfully applied for recovery of analyte in real sample and pharmaceutical sample. A good recovery percentage with lower RSD values depicts the sensitivity and selectivity of the sensor.Jayant I. GowdaRohini M. HanabarattiSuresh M. TuwarElsevierarticlePaclitaxel drugCationic surfactantLimit of detectionPharmaceutical analysisCalibration curveChemistryQD1-999ENResults in Chemistry, Vol 3, Iss , Pp 100243- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Paclitaxel drug Cationic surfactant Limit of detection Pharmaceutical analysis Calibration curve Chemistry QD1-999
spellingShingle	Paclitaxel drug Cationic surfactant Limit of detection Pharmaceutical analysis Calibration curve Chemistry QD1-999 Jayant I. Gowda Rohini M. Hanabaratti Suresh M. Tuwar MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
description	A highly sensitive electrochemical sensor was constructed by layering a MWCNT on a glassy carbon electrode in presence of cationic surfactant, cetyltrimethyl ammonium bromide (CTAB). Surface morphology of developed sensor was carried by AFM technique and used for the electrochemical detection of an anticancer drug paclitaxel (PAC) in pure and dosage form by cyclic and differential pulse voltammetric techniques. Results showed modified sensor exhibited high specific surface area and its morphology consists of very thick and fine particles of MWCNT in presence of surfactant. Optimized the experimental condition by varying the surfactant concentration, accumulation time, buffer pH and scan rate. With standard pH of 7.0, for different scan rate variation (25 to 300 mV/s) a diffusion controlled surface phenomenon was observed on constructed sensor. Detailed electro-chemical oxidation mechanism was proposed based on the obtained result. MWCNT-CTAB/GCE provided lower detection limit and lower quantification limit of 4.38 × 10−10 M and 1.46 × 10−9 M respectively over the concentration ranges of 10.0 × 10−8 and 12.0 × 10−6 M.The MWCNT-CTAB/GCE was successfully applied for recovery of analyte in real sample and pharmaceutical sample. A good recovery percentage with lower RSD values depicts the sensitivity and selectivity of the sensor.
format	article
author	Jayant I. Gowda Rohini M. Hanabaratti Suresh M. Tuwar
author_facet	Jayant I. Gowda Rohini M. Hanabaratti Suresh M. Tuwar
author_sort	Jayant I. Gowda
title	MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
title_short	MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
title_full	MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
title_fullStr	MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
title_full_unstemmed	MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
title_sort	mwcnt modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e08471117c164fed90cff08e06cf50a3
work_keys_str_mv	AT jayantigowda mwcntmodifiedglassycarbonelectrodeinpresenceofcationicsurfactantfortheelectroanalysisofpaclitaxel AT rohinimhanabaratti mwcntmodifiedglassycarbonelectrodeinpresenceofcationicsurfactantfortheelectroanalysisofpaclitaxel AT sureshmtuwar mwcntmodifiedglassycarbonelectrodeinpresenceofcationicsurfactantfortheelectroanalysisofpaclitaxel
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MWCNT modified glassy carbon electrode in presence of cationic surfactant for the electro-analysis of paclitaxel

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