Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome
Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginning to approach that of the general population. Howe...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e08484b1821349199632d845ff4f1872 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e08484b1821349199632d845ff4f1872 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e08484b1821349199632d845ff4f18722021-11-25T18:39:54ZNovel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome10.3390/ph141111701424-8247https://doaj.org/article/e08484b1821349199632d845ff4f18722021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1170https://doaj.org/toc/1424-8247Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginning to approach that of the general population. However, the cognitive deficits seen in individuals with DS still cannot be addressed pharmacologically. In young individuals with DS, the level of intellectual disability varies from mild to severe, but cognitive ability generally decreases with increasing age, and all individuals with DS have early onset Alzheimer’s disease (AD) pathology by the age of 40. The present study introduces a novel inhibitor for the protein kinase DYRK1A, a key controlling kinase whose encoding gene is located on chromosome 21. The novel inhibitor is well characterized for use in mouse models and thus represents a valuable tool compound for further DYRK1A research.Wenche StensenUlli RothweilerRichard Alan EnghMelissa R. StaskoIlya BedermanAlberto C. S. CostaAnders FugelliJohn S. Mjøen SvendsenMDPI AGarticleprotein kinase inhibitorDYRK1Adown syndromeneurodegenerationlearning and memory deficitsmouse modelsMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1170, p 1170 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
protein kinase inhibitor DYRK1A down syndrome neurodegeneration learning and memory deficits mouse models Medicine R Pharmacy and materia medica RS1-441 |
| spellingShingle |
protein kinase inhibitor DYRK1A down syndrome neurodegeneration learning and memory deficits mouse models Medicine R Pharmacy and materia medica RS1-441 Wenche Stensen Ulli Rothweiler Richard Alan Engh Melissa R. Stasko Ilya Bederman Alberto C. S. Costa Anders Fugelli John S. Mjøen Svendsen Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome |
| description |
Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginning to approach that of the general population. However, the cognitive deficits seen in individuals with DS still cannot be addressed pharmacologically. In young individuals with DS, the level of intellectual disability varies from mild to severe, but cognitive ability generally decreases with increasing age, and all individuals with DS have early onset Alzheimer’s disease (AD) pathology by the age of 40. The present study introduces a novel inhibitor for the protein kinase DYRK1A, a key controlling kinase whose encoding gene is located on chromosome 21. The novel inhibitor is well characterized for use in mouse models and thus represents a valuable tool compound for further DYRK1A research. |
| format |
article |
| author |
Wenche Stensen Ulli Rothweiler Richard Alan Engh Melissa R. Stasko Ilya Bederman Alberto C. S. Costa Anders Fugelli John S. Mjøen Svendsen |
| author_facet |
Wenche Stensen Ulli Rothweiler Richard Alan Engh Melissa R. Stasko Ilya Bederman Alberto C. S. Costa Anders Fugelli John S. Mjøen Svendsen |
| author_sort |
Wenche Stensen |
| title |
Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome |
| title_short |
Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome |
| title_full |
Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome |
| title_fullStr |
Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome |
| title_full_unstemmed |
Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome |
| title_sort |
novel dyrk1a inhibitor rescues learning and memory deficits in a mouse model of down syndrome |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/e08484b1821349199632d845ff4f1872 |
| work_keys_str_mv |
AT wenchestensen noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT ullirothweiler noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT richardalanengh noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT melissarstasko noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT ilyabederman noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT albertocscosta noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT andersfugelli noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome AT johnsmjøensvendsen noveldyrk1ainhibitorrescueslearningandmemorydeficitsinamousemodelofdownsyndrome |
| _version_ |
1718410867408633856 |