Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Although ulcerative colitis (UC) is a major type of inflammatory bowel disease, attempts to model it fully have fallen short. Here the authors use patient-derived iPS cells to develop a UC organoid model that recapitulates disease histological and functional features, and confirm the role of CXCL8/C...

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Autores principales:	Samaneh K. Sarvestani, Steven Signs, Bo Hu, Yunku Yeu, Hao Feng, Ying Ni, David R. Hill, Robert C. Fisher, Sylvain Ferrandon, Reece K. DeHaan, Jennifer Stiene, Michael Cruise, Tae Hyun Hwang, Xiling Shen, Jason R. Spence, Emina H. Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0893cff828c448aa384819d64ff53ea
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spelling	oai:doaj.org-article:e0893cff828c448aa384819d64ff53ea2021-12-02T14:12:04ZInduced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity10.1038/s41467-020-20351-52041-1723https://doaj.org/article/e0893cff828c448aa384819d64ff53ea2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20351-5https://doaj.org/toc/2041-1723Although ulcerative colitis (UC) is a major type of inflammatory bowel disease, attempts to model it fully have fallen short. Here the authors use patient-derived iPS cells to develop a UC organoid model that recapitulates disease histological and functional features, and confirm the role of CXCL8/CXCR1 in pathogenesis.Samaneh K. SarvestaniSteven SignsBo HuYunku YeuHao FengYing NiDavid R. HillRobert C. FisherSylvain FerrandonReece K. DeHaanJennifer StieneMichael CruiseTae Hyun HwangXiling ShenJason R. SpenceEmina H. HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samaneh K. Sarvestani Steven Signs Bo Hu Yunku Yeu Hao Feng Ying Ni David R. Hill Robert C. Fisher Sylvain Ferrandon Reece K. DeHaan Jennifer Stiene Michael Cruise Tae Hyun Hwang Xiling Shen Jason R. Spence Emina H. Huang Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
description	Although ulcerative colitis (UC) is a major type of inflammatory bowel disease, attempts to model it fully have fallen short. Here the authors use patient-derived iPS cells to develop a UC organoid model that recapitulates disease histological and functional features, and confirm the role of CXCL8/CXCR1 in pathogenesis.
format	article
author	Samaneh K. Sarvestani Steven Signs Bo Hu Yunku Yeu Hao Feng Ying Ni David R. Hill Robert C. Fisher Sylvain Ferrandon Reece K. DeHaan Jennifer Stiene Michael Cruise Tae Hyun Hwang Xiling Shen Jason R. Spence Emina H. Huang
author_facet	Samaneh K. Sarvestani Steven Signs Bo Hu Yunku Yeu Hao Feng Ying Ni David R. Hill Robert C. Fisher Sylvain Ferrandon Reece K. DeHaan Jennifer Stiene Michael Cruise Tae Hyun Hwang Xiling Shen Jason R. Spence Emina H. Huang
author_sort	Samaneh K. Sarvestani
title	Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
title_short	Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
title_full	Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
title_fullStr	Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
title_full_unstemmed	Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
title_sort	induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0893cff828c448aa384819d64ff53ea
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Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

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