Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splicing for the RON proto-oncogene.

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Autores principales:	Simon Braun, Mihaela Enculescu, Samarth T. Setty, Mariela Cortés-López, Bernardo P. de Almeida, F. X. Reymond Sutandy, Laura Schulz, Anke Busch, Markus Seiler, Stefanie Ebersberger, Nuno L. Barbosa-Morais, Stefan Legewie, Julian König, Kathi Zarnack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e09001a3cedf4849a519718409e93dcf
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spelling	oai:doaj.org-article:e09001a3cedf4849a519718409e93dcf2021-12-02T14:41:17ZDecoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis10.1038/s41467-018-05748-72041-1723https://doaj.org/article/e09001a3cedf4849a519718409e93dcf2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05748-7https://doaj.org/toc/2041-1723Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splicing for the RON proto-oncogene.Simon BraunMihaela EnculescuSamarth T. SettyMariela Cortés-LópezBernardo P. de AlmeidaF. X. Reymond SutandyLaura SchulzAnke BuschMarkus SeilerStefanie EbersbergerNuno L. Barbosa-MoraisStefan LegewieJulian KönigKathi ZarnackNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Braun Mihaela Enculescu Samarth T. Setty Mariela Cortés-López Bernardo P. de Almeida F. X. Reymond Sutandy Laura Schulz Anke Busch Markus Seiler Stefanie Ebersberger Nuno L. Barbosa-Morais Stefan Legewie Julian König Kathi Zarnack Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
description	Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splicing for the RON proto-oncogene.
format	article
author	Simon Braun Mihaela Enculescu Samarth T. Setty Mariela Cortés-López Bernardo P. de Almeida F. X. Reymond Sutandy Laura Schulz Anke Busch Markus Seiler Stefanie Ebersberger Nuno L. Barbosa-Morais Stefan Legewie Julian König Kathi Zarnack
author_facet	Simon Braun Mihaela Enculescu Samarth T. Setty Mariela Cortés-López Bernardo P. de Almeida F. X. Reymond Sutandy Laura Schulz Anke Busch Markus Seiler Stefanie Ebersberger Nuno L. Barbosa-Morais Stefan Legewie Julian König Kathi Zarnack
author_sort	Simon Braun
title	Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
title_short	Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
title_full	Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
title_fullStr	Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
title_full_unstemmed	Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
title_sort	decoding a cancer-relevant splicing decision in the ron proto-oncogene using high-throughput mutagenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e09001a3cedf4849a519718409e93dcf
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Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

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