Human pluripotent reprogramming with CRISPR activators

CRISPRa is an attractive tool for cellular reprogramming due to its multiplexing capacity and direct targeting of genomic loci. Here the authors demonstrate the reprogramming of human fibroblasts into iPSCs, which is enhanced by targeting a conserved Alu-motif.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jere Weltner, Diego Balboa, Shintaro Katayama, Maxim Bespalov, Kaarel Krjutškov, Eeva-Mari Jouhilahti, Ras Trokovic, Juha Kere, Timo Otonkoski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e096854da4ff421abdea9001c9984172
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e096854da4ff421abdea9001c9984172
record_format	dspace
spelling	oai:doaj.org-article:e096854da4ff421abdea9001c99841722021-12-02T16:49:31ZHuman pluripotent reprogramming with CRISPR activators10.1038/s41467-018-05067-x2041-1723https://doaj.org/article/e096854da4ff421abdea9001c99841722018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05067-xhttps://doaj.org/toc/2041-1723CRISPRa is an attractive tool for cellular reprogramming due to its multiplexing capacity and direct targeting of genomic loci. Here the authors demonstrate the reprogramming of human fibroblasts into iPSCs, which is enhanced by targeting a conserved Alu-motif.Jere WeltnerDiego BalboaShintaro KatayamaMaxim BespalovKaarel KrjutškovEeva-Mari JouhilahtiRas TrokovicJuha KereTimo OtonkoskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jere Weltner Diego Balboa Shintaro Katayama Maxim Bespalov Kaarel Krjutškov Eeva-Mari Jouhilahti Ras Trokovic Juha Kere Timo Otonkoski Human pluripotent reprogramming with CRISPR activators
description	CRISPRa is an attractive tool for cellular reprogramming due to its multiplexing capacity and direct targeting of genomic loci. Here the authors demonstrate the reprogramming of human fibroblasts into iPSCs, which is enhanced by targeting a conserved Alu-motif.
format	article
author	Jere Weltner Diego Balboa Shintaro Katayama Maxim Bespalov Kaarel Krjutškov Eeva-Mari Jouhilahti Ras Trokovic Juha Kere Timo Otonkoski
author_facet	Jere Weltner Diego Balboa Shintaro Katayama Maxim Bespalov Kaarel Krjutškov Eeva-Mari Jouhilahti Ras Trokovic Juha Kere Timo Otonkoski
author_sort	Jere Weltner
title	Human pluripotent reprogramming with CRISPR activators
title_short	Human pluripotent reprogramming with CRISPR activators
title_full	Human pluripotent reprogramming with CRISPR activators
title_fullStr	Human pluripotent reprogramming with CRISPR activators
title_full_unstemmed	Human pluripotent reprogramming with CRISPR activators
title_sort	human pluripotent reprogramming with crispr activators
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e096854da4ff421abdea9001c9984172
work_keys_str_mv	AT jereweltner humanpluripotentreprogrammingwithcrispractivators AT diegobalboa humanpluripotentreprogrammingwithcrispractivators AT shintarokatayama humanpluripotentreprogrammingwithcrispractivators AT maximbespalov humanpluripotentreprogrammingwithcrispractivators AT kaarelkrjutskov humanpluripotentreprogrammingwithcrispractivators AT eevamarijouhilahti humanpluripotentreprogrammingwithcrispractivators AT rastrokovic humanpluripotentreprogrammingwithcrispractivators AT juhakere humanpluripotentreprogrammingwithcrispractivators AT timootonkoski humanpluripotentreprogrammingwithcrispractivators
_version_	1718383307654168576

Human pluripotent reprogramming with CRISPR activators

Ejemplares similares