Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus

Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine metabolism and polyamine levels was examined. The re...

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Autores principales:	Jiang Dongmei, Mo Guilin, Jiang Yilong, Kang Bo
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	spermidine putrescine spermine polyamine metabolism hypothalamus Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e098322113ba4f0292e5c55662c6e1e5
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spelling	oai:doaj.org-article:e098322113ba4f0292e5c55662c6e1e52021-12-05T14:10:40ZExogenous spermidine affects polyamine metabolism in the mouse hypothalamus2391-541210.1515/biol-2021-0006https://doaj.org/article/e098322113ba4f0292e5c55662c6e1e52021-01-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0006https://doaj.org/toc/2391-5412Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine metabolism and polyamine levels was examined. The results indicated that treatment with spermidine at 0.05 mg/g (BW) significantly increased the levels of Oaz1 mRNA and protein expression and decreased putrescine content in mouse hypothalamus (p < 0.05). The administration with spermidine at 0.10 mg/g significantly increased the levels of Oaz1, Oaz2, and Odc expression in mouse hypothalamus (p < 0.05). Treatment with spermidine at 0.05 mg/g significantly increased the levels of Ssat mRNA expression and reduced the level of Smo mRNA expression in mouse hypothalamus (p < 0.05). Putrescine concentrations in the hypothalamus after the administration of spermidine at 0.10 and 0.15 mg/g were significantly higher than those in the control group (p < 0.05). The concentration of both spermidine and spermine in the hypothalamus after the administration of spermidine at 0.15 mg/g was decreased significantly (p < 0.05). In summary, our results indicate that exogenous spermidine affects polyamine homeostasis in the mouse hypothalamus by modulating the expression of genes and proteins related to polyamine metabolism.Jiang DongmeiMo GuilinJiang YilongKang BoDe Gruyterarticlespermidineputrescinesperminepolyamine metabolismhypothalamusBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 39-45 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spermidine putrescine spermine polyamine metabolism hypothalamus Biology (General) QH301-705.5
spellingShingle	spermidine putrescine spermine polyamine metabolism hypothalamus Biology (General) QH301-705.5 Jiang Dongmei Mo Guilin Jiang Yilong Kang Bo Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
description	Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine metabolism and polyamine levels was examined. The results indicated that treatment with spermidine at 0.05 mg/g (BW) significantly increased the levels of Oaz1 mRNA and protein expression and decreased putrescine content in mouse hypothalamus (p < 0.05). The administration with spermidine at 0.10 mg/g significantly increased the levels of Oaz1, Oaz2, and Odc expression in mouse hypothalamus (p < 0.05). Treatment with spermidine at 0.05 mg/g significantly increased the levels of Ssat mRNA expression and reduced the level of Smo mRNA expression in mouse hypothalamus (p < 0.05). Putrescine concentrations in the hypothalamus after the administration of spermidine at 0.10 and 0.15 mg/g were significantly higher than those in the control group (p < 0.05). The concentration of both spermidine and spermine in the hypothalamus after the administration of spermidine at 0.15 mg/g was decreased significantly (p < 0.05). In summary, our results indicate that exogenous spermidine affects polyamine homeostasis in the mouse hypothalamus by modulating the expression of genes and proteins related to polyamine metabolism.
format	article
author	Jiang Dongmei Mo Guilin Jiang Yilong Kang Bo
author_facet	Jiang Dongmei Mo Guilin Jiang Yilong Kang Bo
author_sort	Jiang Dongmei
title	Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
title_short	Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
title_full	Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
title_fullStr	Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
title_full_unstemmed	Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
title_sort	exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/e098322113ba4f0292e5c55662c6e1e5
work_keys_str_mv	AT jiangdongmei exogenousspermidineaffectspolyaminemetabolisminthemousehypothalamus AT moguilin exogenousspermidineaffectspolyaminemetabolisminthemousehypothalamus AT jiangyilong exogenousspermidineaffectspolyaminemetabolisminthemousehypothalamus AT kangbo exogenousspermidineaffectspolyaminemetabolisminthemousehypothalamus
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Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus

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