Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.

Daily sessions of therapeutic transcranial brain stimulation are thought to prolong or amplify the effect of a single intervention. Here we show in patients with focal hand dystonia that additional, new effects build up progressively over time, making it difficult to predict the effect of long term...

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Autores principales:	Ying-Zu Huang, Chin-Song Lu, John C Rothwell, Chung-Chuan Lo, Wen-Li Chuang, Yi-Hsin Weng, Szu-Chia Lai, Rou-Shayn Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0985f680fa24a5eb706bdbf753d1962
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spelling	oai:doaj.org-article:e0985f680fa24a5eb706bdbf753d19622021-11-18T08:12:26ZModulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.1932-620310.1371/journal.pone.0047574https://doaj.org/article/e0985f680fa24a5eb706bdbf753d19622012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071824/?tool=EBIhttps://doaj.org/toc/1932-6203Daily sessions of therapeutic transcranial brain stimulation are thought to prolong or amplify the effect of a single intervention. Here we show in patients with focal hand dystonia that additional, new effects build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. In a sham-controlled study, real or sham continuous theta burst stimulation (cTBS) was given once daily for five consecutive days to dorsolateral premotor cortex (PMd). Five days of real, but not sham, premotor cTBS improved intracortical inhibition in primary motor cortex (M1) to a similar extent on day 1 and day 5. However 5 days of cTBS were required to restore the abnormal PMd-M1 interactions observed on day 1. Similarly, excessive M1 plasticity seen at baseline was also significantly reduced by five days of real premotor cTBS. There was only a marginal benefit on writing. The results show that additional, new effects, at sites distant from the point of stimulation, build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. The results indicate that it may take many days of therapeutic intervention to rebalance activity in a complex network.Ying-Zu HuangChin-Song LuJohn C RothwellChung-Chuan LoWen-Li ChuangYi-Hsin WengSzu-Chia LaiRou-Shayn ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47574 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Zu Huang Chin-Song Lu John C Rothwell Chung-Chuan Lo Wen-Li Chuang Yi-Hsin Weng Szu-Chia Lai Rou-Shayn Chen Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
description	Daily sessions of therapeutic transcranial brain stimulation are thought to prolong or amplify the effect of a single intervention. Here we show in patients with focal hand dystonia that additional, new effects build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. In a sham-controlled study, real or sham continuous theta burst stimulation (cTBS) was given once daily for five consecutive days to dorsolateral premotor cortex (PMd). Five days of real, but not sham, premotor cTBS improved intracortical inhibition in primary motor cortex (M1) to a similar extent on day 1 and day 5. However 5 days of cTBS were required to restore the abnormal PMd-M1 interactions observed on day 1. Similarly, excessive M1 plasticity seen at baseline was also significantly reduced by five days of real premotor cTBS. There was only a marginal benefit on writing. The results show that additional, new effects, at sites distant from the point of stimulation, build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. The results indicate that it may take many days of therapeutic intervention to rebalance activity in a complex network.
format	article
author	Ying-Zu Huang Chin-Song Lu John C Rothwell Chung-Chuan Lo Wen-Li Chuang Yi-Hsin Weng Szu-Chia Lai Rou-Shayn Chen
author_facet	Ying-Zu Huang Chin-Song Lu John C Rothwell Chung-Chuan Lo Wen-Li Chuang Yi-Hsin Weng Szu-Chia Lai Rou-Shayn Chen
author_sort	Ying-Zu Huang
title	Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
title_short	Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
title_full	Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
title_fullStr	Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
title_full_unstemmed	Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
title_sort	modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e0985f680fa24a5eb706bdbf753d1962
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Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.

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