Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy...

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Autores principales:	Ladan Khodaparast, Laleh Khodaparast, Rodrigo Gallardo, Nikolaos N. Louros, Emiel Michiels, Reshmi Ramakrishnan, Meine Ramakers, Filip Claes, Lydia Young, Mohammad Shahrooei, Hannah Wilkinson, Matyas Desager, Wubishet Mengistu Tadesse, K. Peter R. Nilsson, Per Hammarström, Abram Aertsen, Sebastien Carpentier, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e099418a872446eeb04f67443f1e8e5e
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spelling	oai:doaj.org-article:e099418a872446eeb04f67443f1e8e5e2021-12-02T14:40:30ZAggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis10.1038/s41467-018-03131-02041-1723https://doaj.org/article/e099418a872446eeb04f67443f1e8e5e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03131-0https://doaj.org/toc/2041-1723Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy.Ladan KhodaparastLaleh KhodaparastRodrigo GallardoNikolaos N. LourosEmiel MichielsReshmi RamakrishnanMeine RamakersFilip ClaesLydia YoungMohammad ShahrooeiHannah WilkinsonMatyas DesagerWubishet Mengistu TadesseK. Peter R. NilssonPer HammarströmAbram AertsenSebastien CarpentierJohan Van EldereFrederic RousseauJoost SchymkowitzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ladan Khodaparast Laleh Khodaparast Rodrigo Gallardo Nikolaos N. Louros Emiel Michiels Reshmi Ramakrishnan Meine Ramakers Filip Claes Lydia Young Mohammad Shahrooei Hannah Wilkinson Matyas Desager Wubishet Mengistu Tadesse K. Peter R. Nilsson Per Hammarström Abram Aertsen Sebastien Carpentier Johan Van Eldere Frederic Rousseau Joost Schymkowitz Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
description	Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy.
format	article
author	Ladan Khodaparast Laleh Khodaparast Rodrigo Gallardo Nikolaos N. Louros Emiel Michiels Reshmi Ramakrishnan Meine Ramakers Filip Claes Lydia Young Mohammad Shahrooei Hannah Wilkinson Matyas Desager Wubishet Mengistu Tadesse K. Peter R. Nilsson Per Hammarström Abram Aertsen Sebastien Carpentier Johan Van Eldere Frederic Rousseau Joost Schymkowitz
author_facet	Ladan Khodaparast Laleh Khodaparast Rodrigo Gallardo Nikolaos N. Louros Emiel Michiels Reshmi Ramakrishnan Meine Ramakers Filip Claes Lydia Young Mohammad Shahrooei Hannah Wilkinson Matyas Desager Wubishet Mengistu Tadesse K. Peter R. Nilsson Per Hammarström Abram Aertsen Sebastien Carpentier Johan Van Eldere Frederic Rousseau Joost Schymkowitz
author_sort	Ladan Khodaparast
title	Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
title_short	Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
title_full	Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
title_fullStr	Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
title_full_unstemmed	Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
title_sort	aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e099418a872446eeb04f67443f1e8e5e
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Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

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