Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alone or in combination with chemotherapy.

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Autores principales:	Sara Badodi, Nicola Pomella, Xinyu Zhang, Gabriel Rosser, John Whittingham, Maria Victoria Niklison-Chirou, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Christopher D. Bennett, Steven C. Clifford, Andrew Peet, M. Albert Basson, Silvia Marino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e099abd2067e489ba7b766a7107a8238
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spelling	oai:doaj.org-article:e099abd2067e489ba7b766a7107a82382021-12-02T14:30:27ZInositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation10.1038/s41467-021-22379-72041-1723https://doaj.org/article/e099abd2067e489ba7b766a7107a82382021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22379-7https://doaj.org/toc/2041-1723BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alone or in combination with chemotherapy.Sara BadodiNicola PomellaXinyu ZhangGabriel RosserJohn WhittinghamMaria Victoria Niklison-ChirouYau Mun LimSebastian BrandnerGillian MorrisonSteven M. PollardChristopher D. BennettSteven C. CliffordAndrew PeetM. Albert BassonSilvia MarinoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Badodi Nicola Pomella Xinyu Zhang Gabriel Rosser John Whittingham Maria Victoria Niklison-Chirou Yau Mun Lim Sebastian Brandner Gillian Morrison Steven M. Pollard Christopher D. Bennett Steven C. Clifford Andrew Peet M. Albert Basson Silvia Marino Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
description	BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alone or in combination with chemotherapy.
format	article
author	Sara Badodi Nicola Pomella Xinyu Zhang Gabriel Rosser John Whittingham Maria Victoria Niklison-Chirou Yau Mun Lim Sebastian Brandner Gillian Morrison Steven M. Pollard Christopher D. Bennett Steven C. Clifford Andrew Peet M. Albert Basson Silvia Marino
author_facet	Sara Badodi Nicola Pomella Xinyu Zhang Gabriel Rosser John Whittingham Maria Victoria Niklison-Chirou Yau Mun Lim Sebastian Brandner Gillian Morrison Steven M. Pollard Christopher D. Bennett Steven C. Clifford Andrew Peet M. Albert Basson Silvia Marino
author_sort	Sara Badodi
title	Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
title_short	Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
title_full	Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
title_fullStr	Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
title_full_unstemmed	Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
title_sort	inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e099abd2067e489ba7b766a7107a8238
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Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

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