Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice

BACKGROUND AND OBJECTIVE: Garlic has been shown to have anti-tumoral and anti-metastatic activities in some kinds of cancer. Therefore, it may be effective against fibrosarcoma. The effect of heating on garlic ingredients and its benefits are not clear. Therefore, in this study the effect of heating...

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Autores principales:	H Shirzad, F Taji, S Raisi, B Pourgheysari, M Rafieian-Kopaei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	fibrosarcoma balb/c mice garlic immune system Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e09d58c06e9c4008b2da804961cf8d75
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spelling	oai:doaj.org-article:e09d58c06e9c4008b2da804961cf8d752021-11-10T08:53:33ZComparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice1561-41072251-7170https://doaj.org/article/e09d58c06e9c4008b2da804961cf8d752012-11-01T00:00:00Zhttp://jbums.org/article-1-4236-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Garlic has been shown to have anti-tumoral and anti-metastatic activities in some kinds of cancer. Therefore, it may be effective against fibrosarcoma. The effect of heating on garlic ingredients and its benefits are not clear. Therefore, in this study the effect of heating of garlic on the growth of WEHI-164fibrosarcoma cells in Balb/c mice was examined. The amounts of phenolic compounds and antioxidant capacity of heated and unheated garlic were also determined.METHODS: In an experimental study 40 inbred Balb/c mice were divided into 5 groups of 8 each. A single aliquot of 5 × 106 cells/100 µl WEHI-164 cells was injected subcutaneously in the chest of each animal. Groups 1, 3 and 5 received normal saline (0.2 ml), heated and unheated garlic (20 mg/kg) for two weeks before and three weeks after cell injection, and groups 2 and 4 received unheated and heated garlic, respectively. The mean size of tumors, antioxidant activity and phenolic compounds were measured and compared with each other.FINDINGS: The mean size of tumor in groups which received unheated garlic extract was smaller than that of heated group. Significant differences could be seen in the final last 6 days of experiment, so that the mean sizes of tumors on the 21st day of study was110±86 mm2in heated and 760±79 mm2in raw garlic groups (p0.05). The amount of total phenolic compounds in raw garlic (12.61 mg/gr) was more than heated garlic (1.07 mg/gr) (p>0.05).CONCLUSION: Garlic consumption may have important role in control and prevention of fibrosarcoma growth. But heating may decrease the phenolic compounds, antioxidant capacity and anticancer effect of garlic.H Shirzad,F TajiS RaisiB PourgheysariM Rafieian-KopaeiBabol University of Medical Sciencesarticlefibrosarcomabalb/c micegarlicimmune systemMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 6, Pp 77-83 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	fibrosarcoma balb/c mice garlic immune system Medicine R Medicine (General) R5-920
spellingShingle	fibrosarcoma balb/c mice garlic immune system Medicine R Medicine (General) R5-920 H Shirzad, F Taji S Raisi B Pourgheysari M Rafieian-Kopaei Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice
description	BACKGROUND AND OBJECTIVE: Garlic has been shown to have anti-tumoral and anti-metastatic activities in some kinds of cancer. Therefore, it may be effective against fibrosarcoma. The effect of heating on garlic ingredients and its benefits are not clear. Therefore, in this study the effect of heating of garlic on the growth of WEHI-164fibrosarcoma cells in Balb/c mice was examined. The amounts of phenolic compounds and antioxidant capacity of heated and unheated garlic were also determined.METHODS: In an experimental study 40 inbred Balb/c mice were divided into 5 groups of 8 each. A single aliquot of 5 × 106 cells/100 µl WEHI-164 cells was injected subcutaneously in the chest of each animal. Groups 1, 3 and 5 received normal saline (0.2 ml), heated and unheated garlic (20 mg/kg) for two weeks before and three weeks after cell injection, and groups 2 and 4 received unheated and heated garlic, respectively. The mean size of tumors, antioxidant activity and phenolic compounds were measured and compared with each other.FINDINGS: The mean size of tumor in groups which received unheated garlic extract was smaller than that of heated group. Significant differences could be seen in the final last 6 days of experiment, so that the mean sizes of tumors on the 21st day of study was110±86 mm2in heated and 760±79 mm2in raw garlic groups (p0.05). The amount of total phenolic compounds in raw garlic (12.61 mg/gr) was more than heated garlic (1.07 mg/gr) (p>0.05).CONCLUSION: Garlic consumption may have important role in control and prevention of fibrosarcoma growth. But heating may decrease the phenolic compounds, antioxidant capacity and anticancer effect of garlic.
format	article
author	H Shirzad, F Taji S Raisi B Pourgheysari M Rafieian-Kopaei
author_facet	H Shirzad, F Taji S Raisi B Pourgheysari M Rafieian-Kopaei
author_sort	H Shirzad,
title	Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice
title_short	Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice
title_full	Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice
title_fullStr	Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice
title_full_unstemmed	Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice
title_sort	comparison of antitumour activities of heated and raw garlic extracts on fibrosarcoma in mice
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/e09d58c06e9c4008b2da804961cf8d75
work_keys_str_mv	AT hshirzad comparisonofantitumouractivitiesofheatedandrawgarlicextractsonfibrosarcomainmice AT ftaji comparisonofantitumouractivitiesofheatedandrawgarlicextractsonfibrosarcomainmice AT sraisi comparisonofantitumouractivitiesofheatedandrawgarlicextractsonfibrosarcomainmice AT bpourgheysari comparisonofantitumouractivitiesofheatedandrawgarlicextractsonfibrosarcomainmice AT mrafieiankopaei comparisonofantitumouractivitiesofheatedandrawgarlicextractsonfibrosarcomainmice
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Comparison of Antitumour Activities of Heated and Raw Garlic Extracts on Fibrosarcoma in Mice

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