Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein

During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory protein acetylation and its dissociation from glu...

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Autores principales:	Hitoshi Watanabe, Yuka Inaba, Kumi Kimura, Michihiro Matsumoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e09d63003b4f4c6d834180b9cb38c390
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spelling	oai:doaj.org-article:e09d63003b4f4c6d834180b9cb38c3902021-12-02T14:39:23ZSirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein10.1038/s41467-017-02537-62041-1723https://doaj.org/article/e09d63003b4f4c6d834180b9cb38c3902018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02537-6https://doaj.org/toc/2041-1723During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory protein acetylation and its dissociation from glucokinase.Hitoshi WatanabeYuka InabaKumi KimuraMichihiro MatsumotoShuichi KanekoMasato KasugaHiroshi InoueNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hitoshi Watanabe Yuka Inaba Kumi Kimura Michihiro Matsumoto Shuichi Kaneko Masato Kasuga Hiroshi Inoue Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
description	During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory protein acetylation and its dissociation from glucokinase.
format	article
author	Hitoshi Watanabe Yuka Inaba Kumi Kimura Michihiro Matsumoto Shuichi Kaneko Masato Kasuga Hiroshi Inoue
author_facet	Hitoshi Watanabe Yuka Inaba Kumi Kimura Michihiro Matsumoto Shuichi Kaneko Masato Kasuga Hiroshi Inoue
author_sort	Hitoshi Watanabe
title	Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
title_short	Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
title_full	Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
title_fullStr	Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
title_full_unstemmed	Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
title_sort	sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e09d63003b4f4c6d834180b9cb38c390
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Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein

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