Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

Abstract Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however the 5-year survival rates remain at < 20%. To improve treatment...

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Main Authors: Amy M. Buckley, Margaret R. Dunne, Maria E. Morrissey, Susan A. Kennedy, Aoife Nolan, Maria Davern, Emma K. Foley, Niamh Clarke, Joanne Lysaght, Narayanasamy Ravi, Dermot O’Toole, Finbar MacCarthy, John V. Reynolds, Breandán N. Kennedy, Jacintha O’Sullivan
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/e0a0a6fa4475406c8c5b27eb5adbbaa8
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