Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation

Fat-associated lymphoid clusters (FALC) in the serous cavities house rapid IgM-producing B1 cells, but how the clusters are activated to respond to infection is unclear. Here the authors show that in response to lung inflammation or pleural nematode infection adipose stromal cell-derived IL-33 activ...

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Autores principales:	Lucy H. Jackson-Jones, Sheelagh M. Duncan, Marlène S. Magalhaes, Sharon M. Campbell, Rick M. Maizels, Henry J. McSorley, Judith E. Allen, Cécile Bénézech
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0a47d8553154a589671384dea2f8cdb
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spelling	oai:doaj.org-article:e0a47d8553154a589671384dea2f8cdb2021-12-02T16:56:47ZFat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation10.1038/ncomms126512041-1723https://doaj.org/article/e0a47d8553154a589671384dea2f8cdb2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12651https://doaj.org/toc/2041-1723Fat-associated lymphoid clusters (FALC) in the serous cavities house rapid IgM-producing B1 cells, but how the clusters are activated to respond to infection is unclear. Here the authors show that in response to lung inflammation or pleural nematode infection adipose stromal cell-derived IL-33 activates ILC2s to produce IL-5, thus driving the B1 response in the FALCs.Lucy H. Jackson-JonesSheelagh M. DuncanMarlène S. MagalhaesSharon M. CampbellRick M. MaizelsHenry J. McSorleyJudith E. AllenCécile BénézechNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucy H. Jackson-Jones Sheelagh M. Duncan Marlène S. Magalhaes Sharon M. Campbell Rick M. Maizels Henry J. McSorley Judith E. Allen Cécile Bénézech Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
description	Fat-associated lymphoid clusters (FALC) in the serous cavities house rapid IgM-producing B1 cells, but how the clusters are activated to respond to infection is unclear. Here the authors show that in response to lung inflammation or pleural nematode infection adipose stromal cell-derived IL-33 activates ILC2s to produce IL-5, thus driving the B1 response in the FALCs.
format	article
author	Lucy H. Jackson-Jones Sheelagh M. Duncan Marlène S. Magalhaes Sharon M. Campbell Rick M. Maizels Henry J. McSorley Judith E. Allen Cécile Bénézech
author_facet	Lucy H. Jackson-Jones Sheelagh M. Duncan Marlène S. Magalhaes Sharon M. Campbell Rick M. Maizels Henry J. McSorley Judith E. Allen Cécile Bénézech
author_sort	Lucy H. Jackson-Jones
title	Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
title_short	Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
title_full	Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
title_fullStr	Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
title_full_unstemmed	Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
title_sort	fat-associated lymphoid clusters control local igm secretion during pleural infection and lung inflammation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e0a47d8553154a589671384dea2f8cdb
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Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation

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