Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria

Ming Gao,1 Run Chang,1 Danquan Wang,2 Yuan Li,1 Linlin Sun,1 Steven R Lustig,1 Thomas J Webster1,3 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; 3Wenzhou Institute of Biomat...

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Autores principales:	Gao M, Chang R, Wang D, Li Y, Sun L, Lustig SR, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	mrsa mdr-e.coli bacteria fructose antibiotic resistance nano peptide amphiphiles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e0a51332e3154bd9ac00621ecd4b0855
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spelling	oai:doaj.org-article:e0a51332e3154bd9ac00621ecd4b08552021-12-02T08:11:37ZShort Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria1178-2013https://doaj.org/article/e0a51332e3154bd9ac00621ecd4b08552020-01-01T00:00:00Zhttps://www.dovepress.com/short-communication-fructose-enhanced-antibacterial-activity-of-self-a-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming Gao,1 Run Chang,1 Danquan Wang,2 Yuan Li,1 Linlin Sun,1 Steven R Lustig,1 Thomas J Webster1,3 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; 3Wenzhou Institute of Biomaterials and Engineering, Wenzhou, People’s Republic of ChinaCorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 313 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115, USATel +1 617 373 6585Fax +1 617 373 2209Email th.webster@neu.eduBackground: In recent years, numerous bacteria have become resistant to conventional antibiotics. Fortunately, an increasing body of research indicates that through the addition of specific metabolites (like sugars), the antibacterial activity of certain drugs can be enhanced. A new type of self-assembled nano-peptide amphiphile (SANPA) was designed in this study to treat antibiotic-resistant bacterial infections and to reduce the use of antibiotics.Methods: Here, SANPAs were self-assembled into nanorod structures with a diameter of ca. 10.5 nm at concentrations greater than the critical micelle concentration (CMC) of 44.67 μM. Both Gram-positive and Gram-negative bacteria were treated with SANPAs with fructose supplementation.Results: After a 30-min fructose pre-incubation, SANPAs reduced bacteria growth relative to non-fructose treatments at all concentrations. Cytotoxicity assays indicated that the presence of fructose seemed to slightly ameliorate the cytotoxic effect of the treatment on model human fetal osteoblasts (or bone-forming cells) and human dermal fibroblasts.Conclusion: We demonstrated here that SANPAs-like nanomaterials have a promising potential to treat antibiotic-resistant bacteria, especially when added to fructose, potentially limiting their associated infections.Keywords: MRSA, MDR-E.coli, bacteria, fructose, antibiotic resistance, nano peptide amphiphilesGao MChang RWang DLi YSun LLustig SRWebster TJDove Medical Pressarticlemrsamdr-e.colibacteriafructoseantibiotic resistancenano peptide amphiphilesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 513-519 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mrsa mdr-e.coli bacteria fructose antibiotic resistance nano peptide amphiphiles Medicine (General) R5-920
spellingShingle	mrsa mdr-e.coli bacteria fructose antibiotic resistance nano peptide amphiphiles Medicine (General) R5-920 Gao M Chang R Wang D Li Y Sun L Lustig SR Webster TJ Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria
description	Ming Gao,1 Run Chang,1 Danquan Wang,2 Yuan Li,1 Linlin Sun,1 Steven R Lustig,1 Thomas J Webster1,3 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; 3Wenzhou Institute of Biomaterials and Engineering, Wenzhou, People’s Republic of ChinaCorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 313 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115, USATel +1 617 373 6585Fax +1 617 373 2209Email th.webster@neu.eduBackground: In recent years, numerous bacteria have become resistant to conventional antibiotics. Fortunately, an increasing body of research indicates that through the addition of specific metabolites (like sugars), the antibacterial activity of certain drugs can be enhanced. A new type of self-assembled nano-peptide amphiphile (SANPA) was designed in this study to treat antibiotic-resistant bacterial infections and to reduce the use of antibiotics.Methods: Here, SANPAs were self-assembled into nanorod structures with a diameter of ca. 10.5 nm at concentrations greater than the critical micelle concentration (CMC) of 44.67 μM. Both Gram-positive and Gram-negative bacteria were treated with SANPAs with fructose supplementation.Results: After a 30-min fructose pre-incubation, SANPAs reduced bacteria growth relative to non-fructose treatments at all concentrations. Cytotoxicity assays indicated that the presence of fructose seemed to slightly ameliorate the cytotoxic effect of the treatment on model human fetal osteoblasts (or bone-forming cells) and human dermal fibroblasts.Conclusion: We demonstrated here that SANPAs-like nanomaterials have a promising potential to treat antibiotic-resistant bacteria, especially when added to fructose, potentially limiting their associated infections.Keywords: MRSA, MDR-E.coli, bacteria, fructose, antibiotic resistance, nano peptide amphiphiles
format	article
author	Gao M Chang R Wang D Li Y Sun L Lustig SR Webster TJ
author_facet	Gao M Chang R Wang D Li Y Sun L Lustig SR Webster TJ
author_sort	Gao M
title	Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria
title_short	Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria
title_full	Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria
title_fullStr	Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria
title_full_unstemmed	Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria
title_sort	short communication: fructose-enhanced antibacterial activity of self-assembled nano-peptide amphiphiles for treating antibiotic-resistant bacteria
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e0a51332e3154bd9ac00621ecd4b0855
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Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria

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