Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.

<h4>Background</h4>Despite impressive advances in our understanding of the biology of novel influenza A(H1N1) virus, little is as yet known about its transmission efficiency in close contact places such as households, schools, and workplaces. These are widely believed to be key in suppor...

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Autores principales: Michiel van Boven, Tjibbe Donker, Mariken van der Lubben, Rianne B van Gageldonk-Lafeber, Dennis E te Beest, Marion Koopmans, Adam Meijer, Aura Timen, Corien Swaan, Anton Dalhuijsen, Susan Hahné, Anneke van den Hoek, Peter Teunis, Marianne A B van der Sande, Jacco Wallinga
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Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/e0a7da82af464de3b4cc1b01c871056a
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spelling oai:doaj.org-article:e0a7da82af464de3b4cc1b01c871056a2021-12-02T20:20:16ZTransmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.1932-620310.1371/journal.pone.0011442https://doaj.org/article/e0a7da82af464de3b4cc1b01c871056a2010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20628642/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Despite impressive advances in our understanding of the biology of novel influenza A(H1N1) virus, little is as yet known about its transmission efficiency in close contact places such as households, schools, and workplaces. These are widely believed to be key in supporting propagating spread, and it is therefore of importance to assess the transmission levels of the virus in such settings.<h4>Methodology/principal findings</h4>We estimate the transmissibility of novel influenza A(H1N1) in 47 households in the Netherlands using stochastic epidemic models. All households contained a laboratory confirmed index case, and antiviral drugs (oseltamivir) were given to both the index case and other households members within 24 hours after detection of the index case. Among the 109 household contacts there were 9 secondary infections in 7 households. The overall estimated secondary attack rate is low (0.075, 95%CI: 0.037-0.13). There is statistical evidence indicating that older persons are less susceptible to infection than younger persons (relative susceptibility of older persons: 0.11, 95%CI: 0.024-0.43. Notably, the secondary attack rate from an older to a younger person is 0.35 (95%CI: 0.14-0.61) when using an age classification of <or=12 versus >12 years, and 0.28 (95%CI: 0.12-0.50) when using an age classification of <or=18 versus >18 years.<h4>Conclusions/significance</h4>Our results indicate that the overall household transmission levels of novel influenza A(H1N1) in antiviral-treated households were low in the early stage of the epidemic. The relatively high rate of adult-to-child transmission indicates that control measures focused on this transmission route will be most effective in minimizing the total number of infections.Michiel van BovenTjibbe DonkerMariken van der LubbenRianne B van Gageldonk-LafeberDennis E te BeestMarion KoopmansAdam MeijerAura TimenCorien SwaanAnton DalhuijsenSusan HahnéAnneke van den HoekPeter TeunisMarianne A B van der SandeJacco WallingaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11442 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Michiel van Boven
Tjibbe Donker
Mariken van der Lubben
Rianne B van Gageldonk-Lafeber
Dennis E te Beest
Marion Koopmans
Adam Meijer
Aura Timen
Corien Swaan
Anton Dalhuijsen
Susan Hahné
Anneke van den Hoek
Peter Teunis
Marianne A B van der Sande
Jacco Wallinga
Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.
description <h4>Background</h4>Despite impressive advances in our understanding of the biology of novel influenza A(H1N1) virus, little is as yet known about its transmission efficiency in close contact places such as households, schools, and workplaces. These are widely believed to be key in supporting propagating spread, and it is therefore of importance to assess the transmission levels of the virus in such settings.<h4>Methodology/principal findings</h4>We estimate the transmissibility of novel influenza A(H1N1) in 47 households in the Netherlands using stochastic epidemic models. All households contained a laboratory confirmed index case, and antiviral drugs (oseltamivir) were given to both the index case and other households members within 24 hours after detection of the index case. Among the 109 household contacts there were 9 secondary infections in 7 households. The overall estimated secondary attack rate is low (0.075, 95%CI: 0.037-0.13). There is statistical evidence indicating that older persons are less susceptible to infection than younger persons (relative susceptibility of older persons: 0.11, 95%CI: 0.024-0.43. Notably, the secondary attack rate from an older to a younger person is 0.35 (95%CI: 0.14-0.61) when using an age classification of <or=12 versus >12 years, and 0.28 (95%CI: 0.12-0.50) when using an age classification of <or=18 versus >18 years.<h4>Conclusions/significance</h4>Our results indicate that the overall household transmission levels of novel influenza A(H1N1) in antiviral-treated households were low in the early stage of the epidemic. The relatively high rate of adult-to-child transmission indicates that control measures focused on this transmission route will be most effective in minimizing the total number of infections.
format article
author Michiel van Boven
Tjibbe Donker
Mariken van der Lubben
Rianne B van Gageldonk-Lafeber
Dennis E te Beest
Marion Koopmans
Adam Meijer
Aura Timen
Corien Swaan
Anton Dalhuijsen
Susan Hahné
Anneke van den Hoek
Peter Teunis
Marianne A B van der Sande
Jacco Wallinga
author_facet Michiel van Boven
Tjibbe Donker
Mariken van der Lubben
Rianne B van Gageldonk-Lafeber
Dennis E te Beest
Marion Koopmans
Adam Meijer
Aura Timen
Corien Swaan
Anton Dalhuijsen
Susan Hahné
Anneke van den Hoek
Peter Teunis
Marianne A B van der Sande
Jacco Wallinga
author_sort Michiel van Boven
title Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.
title_short Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.
title_full Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.
title_fullStr Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.
title_full_unstemmed Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.
title_sort transmission of novel influenza a(h1n1) in households with post-exposure antiviral prophylaxis.
publisher Public Library of Science (PLoS)
publishDate 2010
url https://doaj.org/article/e0a7da82af464de3b4cc1b01c871056a
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