Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses

Abstract The ability of humans to discriminate enantiomeric odour pairs is substance –specific. Current literature suggests that psychophysical discrimination of odour enantiomers mainly depends on the peripheral processing at the level of the olfactory sensory neurons (OSN). To study the influence...

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Autores principales:	Sophia C. Poletti, Annachiara Cavazzana, Cagdas Guducu, Maria Larsson, Thomas Hummel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0a8b7422b7d465e97f8d4473857a1f2
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spelling	oai:doaj.org-article:e0a8b7422b7d465e97f8d4473857a1f22021-12-02T16:06:50ZIndistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses10.1038/s41598-017-09594-32045-2322https://doaj.org/article/e0a8b7422b7d465e97f8d4473857a1f22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09594-3https://doaj.org/toc/2045-2322Abstract The ability of humans to discriminate enantiomeric odour pairs is substance –specific. Current literature suggests that psychophysical discrimination of odour enantiomers mainly depends on the peripheral processing at the level of the olfactory sensory neurons (OSN). To study the influence of central processing in discrimination, we investigated differences in the electrophysiological responses to psychophysically indistinguishable (+)- and (−)- rose oxide enantiomers at peripheral and central-nervous levels in humans. We recorded the electro-olfactogram (EOG) from the olfactory epithelium and the EEG-derived olfactory event-related potentials (OERP). Results from a psychophysical three alternative forced choice test indicated indistinguishability of the two odour enantiomers. In a total of 19 young participants EOG could be recorded in 74 and OERP in 95% of subjects. Significantly different EOG amplitudes and latencies were recorded in response to the 2 stimuli. However, no such differences in amplitude or latency emerged for the OERP. In conclusion, although the pair of enantiomer could be discriminated at a peripheral level this did not lead to a central-nervous/cognitive differentiation of the two stimuli.Sophia C. PolettiAnnachiara CavazzanaCagdas GuducuMaria LarssonThomas HummelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophia C. Poletti Annachiara Cavazzana Cagdas Guducu Maria Larsson Thomas Hummel Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
description	Abstract The ability of humans to discriminate enantiomeric odour pairs is substance –specific. Current literature suggests that psychophysical discrimination of odour enantiomers mainly depends on the peripheral processing at the level of the olfactory sensory neurons (OSN). To study the influence of central processing in discrimination, we investigated differences in the electrophysiological responses to psychophysically indistinguishable (+)- and (−)- rose oxide enantiomers at peripheral and central-nervous levels in humans. We recorded the electro-olfactogram (EOG) from the olfactory epithelium and the EEG-derived olfactory event-related potentials (OERP). Results from a psychophysical three alternative forced choice test indicated indistinguishability of the two odour enantiomers. In a total of 19 young participants EOG could be recorded in 74 and OERP in 95% of subjects. Significantly different EOG amplitudes and latencies were recorded in response to the 2 stimuli. However, no such differences in amplitude or latency emerged for the OERP. In conclusion, although the pair of enantiomer could be discriminated at a peripheral level this did not lead to a central-nervous/cognitive differentiation of the two stimuli.
format	article
author	Sophia C. Poletti Annachiara Cavazzana Cagdas Guducu Maria Larsson Thomas Hummel
author_facet	Sophia C. Poletti Annachiara Cavazzana Cagdas Guducu Maria Larsson Thomas Hummel
author_sort	Sophia C. Poletti
title	Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
title_short	Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
title_full	Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
title_fullStr	Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
title_full_unstemmed	Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
title_sort	indistinguishable odour enantiomers: differences between peripheral and central-nervous electrophysiological responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e0a8b7422b7d465e97f8d4473857a1f2
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Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses

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