Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth

Abstract Hemangioendothelioma (HE) is a type of angiomatous lesions that features endothelial cell proliferation. Understanding the mechanisms orchestrating HE angiogenesis can provide therapeutic insights. It has been shown that platelets can support normal and malignant endothelial cells during an...

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Autores principales:	Rui Gu, Xin Sun, Yijie Chi, Qishuang Zhou, Hongkai Xiang, Dale B. Bosco, Xinhe Lai, Caixia Qin, Kwok-Fai So, Yi Ren, Xiao-Ming Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0abce08e78346e993db0f2aae090a4c
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spelling	oai:doaj.org-article:e0abce08e78346e993db0f2aae090a4c2021-12-02T11:41:20ZIntegrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth10.1038/s41598-017-06927-02045-2322https://doaj.org/article/e0abce08e78346e993db0f2aae090a4c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06927-0https://doaj.org/toc/2045-2322Abstract Hemangioendothelioma (HE) is a type of angiomatous lesions that features endothelial cell proliferation. Understanding the mechanisms orchestrating HE angiogenesis can provide therapeutic insights. It has been shown that platelets can support normal and malignant endothelial cells during angiogenesis. Using the mouse endothelial-derived EOMA cell line as a model of HE, we explored the regulatory effect of platelets. We found that platelets stimulated EOMA proliferation but did not mitigate apoptosis. Furthermore, direct platelet-EOMA cell contact was required and the proliferation was mediated via integrin β3/Akt signaling in EOMA cells. SiRNA knockdown of integrin β3 and inhibition of Akt activity significantly abolished platelet-induced EOMA cell proliferation in vitro and tumor development in vivo. These results provide a new mechanism by which platelets support HE progression and suggest integrin β3 as a potential target to treat HE.Rui GuXin SunYijie ChiQishuang ZhouHongkai XiangDale B. BoscoXinhe LaiCaixia QinKwok-Fai SoYi RenXiao-Ming ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui Gu Xin Sun Yijie Chi Qishuang Zhou Hongkai Xiang Dale B. Bosco Xinhe Lai Caixia Qin Kwok-Fai So Yi Ren Xiao-Ming Chen Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth
description	Abstract Hemangioendothelioma (HE) is a type of angiomatous lesions that features endothelial cell proliferation. Understanding the mechanisms orchestrating HE angiogenesis can provide therapeutic insights. It has been shown that platelets can support normal and malignant endothelial cells during angiogenesis. Using the mouse endothelial-derived EOMA cell line as a model of HE, we explored the regulatory effect of platelets. We found that platelets stimulated EOMA proliferation but did not mitigate apoptosis. Furthermore, direct platelet-EOMA cell contact was required and the proliferation was mediated via integrin β3/Akt signaling in EOMA cells. SiRNA knockdown of integrin β3 and inhibition of Akt activity significantly abolished platelet-induced EOMA cell proliferation in vitro and tumor development in vivo. These results provide a new mechanism by which platelets support HE progression and suggest integrin β3 as a potential target to treat HE.
format	article
author	Rui Gu Xin Sun Yijie Chi Qishuang Zhou Hongkai Xiang Dale B. Bosco Xinhe Lai Caixia Qin Kwok-Fai So Yi Ren Xiao-Ming Chen
author_facet	Rui Gu Xin Sun Yijie Chi Qishuang Zhou Hongkai Xiang Dale B. Bosco Xinhe Lai Caixia Qin Kwok-Fai So Yi Ren Xiao-Ming Chen
author_sort	Rui Gu
title	Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth
title_short	Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth
title_full	Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth
title_fullStr	Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth
title_full_unstemmed	Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth
title_sort	integrin β3/akt signaling contributes to platelet-induced hemangioendothelioma growth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e0abce08e78346e993db0f2aae090a4c
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Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth

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