Pathological conversion of regulatory T cells is associated with loss of allotolerance

Pathological conversion of regulatory T cells is associated with loss of allotolerance

Abstract CD4+CD25+Foxp3+ Regulatory T cells (Tregs) play a critical role in immune tolerance. The plasticity and functional adaptability of Tregs in an inflammatory microenvironment has been demonstrated in autoimmunity. Here, using a double transgenic mouse model that permits Foxp3 lineage tracing,...

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Autores principales: Jing Hua, Takenori Inomata, Yihe Chen, William Foulsham, William Stevenson, Tina Shiang, Jeffrey A. Bluestone, Reza Dana
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e0acee4685d7438c894e55fd71ae9255
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