Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures

Complete gene expression deconvolution remains a challenging problem. Here, the authors provide a solution based on the recognition that expression levels of cell type specific genes are mutually linear across mixtures and mutually linear gene clusters correspond to cell type-specific signatures.

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Autores principales:	Konstantin Zaitsev, Monika Bambouskova, Amanda Swain, Maxim N. Artyomov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0ae9b56ce5441f49af3e03ef9d412aa
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spelling	oai:doaj.org-article:e0ae9b56ce5441f49af3e03ef9d412aa2021-12-02T14:38:42ZComplete deconvolution of cellular mixtures based on linearity of transcriptional signatures10.1038/s41467-019-09990-52041-1723https://doaj.org/article/e0ae9b56ce5441f49af3e03ef9d412aa2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09990-5https://doaj.org/toc/2041-1723Complete gene expression deconvolution remains a challenging problem. Here, the authors provide a solution based on the recognition that expression levels of cell type specific genes are mutually linear across mixtures and mutually linear gene clusters correspond to cell type-specific signatures.Konstantin ZaitsevMonika BambouskovaAmanda SwainMaxim N. ArtyomovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konstantin Zaitsev Monika Bambouskova Amanda Swain Maxim N. Artyomov Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
description	Complete gene expression deconvolution remains a challenging problem. Here, the authors provide a solution based on the recognition that expression levels of cell type specific genes are mutually linear across mixtures and mutually linear gene clusters correspond to cell type-specific signatures.
format	article
author	Konstantin Zaitsev Monika Bambouskova Amanda Swain Maxim N. Artyomov
author_facet	Konstantin Zaitsev Monika Bambouskova Amanda Swain Maxim N. Artyomov
author_sort	Konstantin Zaitsev
title	Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
title_short	Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
title_full	Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
title_fullStr	Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
title_full_unstemmed	Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
title_sort	complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e0ae9b56ce5441f49af3e03ef9d412aa
work_keys_str_mv	AT konstantinzaitsev completedeconvolutionofcellularmixturesbasedonlinearityoftranscriptionalsignatures AT monikabambouskova completedeconvolutionofcellularmixturesbasedonlinearityoftranscriptionalsignatures AT amandaswain completedeconvolutionofcellularmixturesbasedonlinearityoftranscriptionalsignatures AT maximnartyomov completedeconvolutionofcellularmixturesbasedonlinearityoftranscriptionalsignatures
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Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures

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