A single baroreceptor unit consists of multiple sensors

Abstract Arterial baroreceptors (BRs) play a vital role in the regulation of the cardiopulmonary system. What is known about how these sensors operate at the subcellular level is limited, however. Until recently, one afferent axon was considered to be connected to a single baroreceptor (one-sensor t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jun Liu, Nana Song, Yufang Wang, Jerome Walker, Jerry Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0b02220df5c48cda510055205913c19
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e0b02220df5c48cda510055205913c19
record_format	dspace
spelling	oai:doaj.org-article:e0b02220df5c48cda510055205913c192021-12-05T12:12:24ZA single baroreceptor unit consists of multiple sensors10.1038/s41598-021-02563-x2045-2322https://doaj.org/article/e0b02220df5c48cda510055205913c192021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02563-xhttps://doaj.org/toc/2045-2322Abstract Arterial baroreceptors (BRs) play a vital role in the regulation of the cardiopulmonary system. What is known about how these sensors operate at the subcellular level is limited, however. Until recently, one afferent axon was considered to be connected to a single baroreceptor (one-sensor theory). However, in the lung, a single airway mechanosensory unit is now known to house many sensors (multiple-sensor theory). Here we tested the hypothesis that multiple-sensor theory also operates in BR units, using both morphological and electrophysiological approaches in rabbit aortic arch (in whole mount) labeled with Na+/K+-ATPase, as well as myelin basic protein antibodies, and examined microscopically. Sensory structures presented in compact clusters, similar to bunches of grapes. Sensory terminals, like those in the airways, formed leaf-like or knob-like expansions. That is, a single myelinated axon connected with multiple sensors forming a network. We also recorded single-unit activities from aortic baroreceptors in the depressor nerve in anesthetized rabbits and examined the unit response to a bolus intravenous injection of phenylephrine. Unit activity increased progressively as blood pressure (BP) increased. Five of eleven units abruptly changed their discharge pattern to a lower activity level after BP attained a plateau for a minute or two (when BP was maintained at the high level). These findings clearly show that the high discharge baroreceptor deactivates after over-excitation and unit activity falls to a low discharge sensor. In conclusion, our morphological and physiological data support the hypothesis that multiple-sensory theory can be applied to BR units.Jun LiuNana SongYufang WangJerome WalkerJerry YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Liu Nana Song Yufang Wang Jerome Walker Jerry Yu A single baroreceptor unit consists of multiple sensors
description	Abstract Arterial baroreceptors (BRs) play a vital role in the regulation of the cardiopulmonary system. What is known about how these sensors operate at the subcellular level is limited, however. Until recently, one afferent axon was considered to be connected to a single baroreceptor (one-sensor theory). However, in the lung, a single airway mechanosensory unit is now known to house many sensors (multiple-sensor theory). Here we tested the hypothesis that multiple-sensor theory also operates in BR units, using both morphological and electrophysiological approaches in rabbit aortic arch (in whole mount) labeled with Na+/K+-ATPase, as well as myelin basic protein antibodies, and examined microscopically. Sensory structures presented in compact clusters, similar to bunches of grapes. Sensory terminals, like those in the airways, formed leaf-like or knob-like expansions. That is, a single myelinated axon connected with multiple sensors forming a network. We also recorded single-unit activities from aortic baroreceptors in the depressor nerve in anesthetized rabbits and examined the unit response to a bolus intravenous injection of phenylephrine. Unit activity increased progressively as blood pressure (BP) increased. Five of eleven units abruptly changed their discharge pattern to a lower activity level after BP attained a plateau for a minute or two (when BP was maintained at the high level). These findings clearly show that the high discharge baroreceptor deactivates after over-excitation and unit activity falls to a low discharge sensor. In conclusion, our morphological and physiological data support the hypothesis that multiple-sensory theory can be applied to BR units.
format	article
author	Jun Liu Nana Song Yufang Wang Jerome Walker Jerry Yu
author_facet	Jun Liu Nana Song Yufang Wang Jerome Walker Jerry Yu
author_sort	Jun Liu
title	A single baroreceptor unit consists of multiple sensors
title_short	A single baroreceptor unit consists of multiple sensors
title_full	A single baroreceptor unit consists of multiple sensors
title_fullStr	A single baroreceptor unit consists of multiple sensors
title_full_unstemmed	A single baroreceptor unit consists of multiple sensors
title_sort	single baroreceptor unit consists of multiple sensors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0b02220df5c48cda510055205913c19
work_keys_str_mv	AT junliu asinglebaroreceptorunitconsistsofmultiplesensors AT nanasong asinglebaroreceptorunitconsistsofmultiplesensors AT yufangwang asinglebaroreceptorunitconsistsofmultiplesensors AT jeromewalker asinglebaroreceptorunitconsistsofmultiplesensors AT jerryyu asinglebaroreceptorunitconsistsofmultiplesensors AT junliu singlebaroreceptorunitconsistsofmultiplesensors AT nanasong singlebaroreceptorunitconsistsofmultiplesensors AT yufangwang singlebaroreceptorunitconsistsofmultiplesensors AT jeromewalker singlebaroreceptorunitconsistsofmultiplesensors AT jerryyu singlebaroreceptorunitconsistsofmultiplesensors
_version_	1718372165695307776

A single baroreceptor unit consists of multiple sensors

Ejemplares similares