Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

Retinitis pigmentosa is mainly caused by mutations that initially affect survival of rod photoreceptors, leading to secondary loss of cones. Here the authors use gene editing to prevent rod degeneration, leading to survival of cones and improved vision in mice.

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Bibliographic Details
Main Authors:	Wenhan Yu, Suddhasil Mookherjee, Vijender Chaitankar, Suja Hiriyanna, Jung-Woong Kim, Matthew Brooks, Yasaman Ataeijannati, Xun Sun, Lijin Dong, Tiansen Li, Anand Swaroop, Zhijian Wu
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/e0b1cb7c443d40f286826b3ebf8c7902
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spelling	oai:doaj.org-article:e0b1cb7c443d40f286826b3ebf8c79022021-12-02T14:42:18ZNrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice10.1038/ncomms147162041-1723https://doaj.org/article/e0b1cb7c443d40f286826b3ebf8c79022017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14716https://doaj.org/toc/2041-1723Retinitis pigmentosa is mainly caused by mutations that initially affect survival of rod photoreceptors, leading to secondary loss of cones. Here the authors use gene editing to prevent rod degeneration, leading to survival of cones and improved vision in mice.Wenhan YuSuddhasil MookherjeeVijender ChaitankarSuja HiriyannaJung-Woong KimMatthew BrooksYasaman AtaeijannatiXun SunLijin DongTiansen LiAnand SwaroopZhijian WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenhan Yu Suddhasil Mookherjee Vijender Chaitankar Suja Hiriyanna Jung-Woong Kim Matthew Brooks Yasaman Ataeijannati Xun Sun Lijin Dong Tiansen Li Anand Swaroop Zhijian Wu Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
description	Retinitis pigmentosa is mainly caused by mutations that initially affect survival of rod photoreceptors, leading to secondary loss of cones. Here the authors use gene editing to prevent rod degeneration, leading to survival of cones and improved vision in mice.
format	article
author	Wenhan Yu Suddhasil Mookherjee Vijender Chaitankar Suja Hiriyanna Jung-Woong Kim Matthew Brooks Yasaman Ataeijannati Xun Sun Lijin Dong Tiansen Li Anand Swaroop Zhijian Wu
author_facet	Wenhan Yu Suddhasil Mookherjee Vijender Chaitankar Suja Hiriyanna Jung-Woong Kim Matthew Brooks Yasaman Ataeijannati Xun Sun Lijin Dong Tiansen Li Anand Swaroop Zhijian Wu
author_sort	Wenhan Yu
title	Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
title_short	Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
title_full	Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
title_fullStr	Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
title_full_unstemmed	Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
title_sort	nrl knockdown by aav-delivered crispr/cas9 prevents retinal degeneration in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e0b1cb7c443d40f286826b3ebf8c7902
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Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

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