The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound P...

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Autores principales:	Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenning Zhu, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e
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spelling	oai:doaj.org-article:e0b510d04f0846f9afbec3f3b04bc27e2021-12-02T13:51:03ZThe complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery10.1038/s41467-020-20718-82041-1723https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20718-8https://doaj.org/toc/2041-1723The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound PLpro crystal structure and NMR studies.Ziyang FuBin HuangJinle TangShuyan LiuMing LiuYuxin YeZhihong LiuYuxian XiongWenning ZhuDan CaoJihui LiXiaogang NiuHuan ZhouYong Juan ZhaoGuoliang ZhangHao HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ziyang Fu Bin Huang Jinle Tang Shuyan Liu Ming Liu Yuxin Ye Zhihong Liu Yuxian Xiong Wenning Zhu Dan Cao Jihui Li Xiaogang Niu Huan Zhou Yong Juan Zhao Guoliang Zhang Hao Huang The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
description	The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound PLpro crystal structure and NMR studies.
format	article
author	Ziyang Fu Bin Huang Jinle Tang Shuyan Liu Ming Liu Yuxin Ye Zhihong Liu Yuxian Xiong Wenning Zhu Dan Cao Jihui Li Xiaogang Niu Huan Zhou Yong Juan Zhao Guoliang Zhang Hao Huang
author_facet	Ziyang Fu Bin Huang Jinle Tang Shuyan Liu Ming Liu Yuxin Ye Zhihong Liu Yuxian Xiong Wenning Zhu Dan Cao Jihui Li Xiaogang Niu Huan Zhou Yong Juan Zhao Guoliang Zhang Hao Huang
author_sort	Ziyang Fu
title	The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
title_short	The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
title_full	The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
title_fullStr	The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
title_full_unstemmed	The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
title_sort	complex structure of grl0617 and sars-cov-2 plpro reveals a hot spot for antiviral drug discovery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e
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The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

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