Tunable light and drug induced depletion of target proteins

Methods to control protein degradation usually require prior genetic engineering of each specific protein of interest. Here the authors present a toolbox for targeted depletion of endogenous proteins in cells and organisms, which is based on light- and drug-controlled recombinant E3 ubiquitin ligase...

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Autores principales:	Wen Deng, Jack A. Bates, Hai Wei, Michael D. Bartoschek, Barbara Conradt, Heinrich Leonhardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0b9331a777b4a65a1b6e1126958bf30
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spelling	oai:doaj.org-article:e0b9331a777b4a65a1b6e1126958bf302021-12-02T14:40:51ZTunable light and drug induced depletion of target proteins10.1038/s41467-019-14160-82041-1723https://doaj.org/article/e0b9331a777b4a65a1b6e1126958bf302020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14160-8https://doaj.org/toc/2041-1723Methods to control protein degradation usually require prior genetic engineering of each specific protein of interest. Here the authors present a toolbox for targeted depletion of endogenous proteins in cells and organisms, which is based on light- and drug-controlled recombinant E3 ubiquitin ligases.Wen DengJack A. BatesHai WeiMichael D. BartoschekBarbara ConradtHeinrich LeonhardtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Deng Jack A. Bates Hai Wei Michael D. Bartoschek Barbara Conradt Heinrich Leonhardt Tunable light and drug induced depletion of target proteins
description	Methods to control protein degradation usually require prior genetic engineering of each specific protein of interest. Here the authors present a toolbox for targeted depletion of endogenous proteins in cells and organisms, which is based on light- and drug-controlled recombinant E3 ubiquitin ligases.
format	article
author	Wen Deng Jack A. Bates Hai Wei Michael D. Bartoschek Barbara Conradt Heinrich Leonhardt
author_facet	Wen Deng Jack A. Bates Hai Wei Michael D. Bartoschek Barbara Conradt Heinrich Leonhardt
author_sort	Wen Deng
title	Tunable light and drug induced depletion of target proteins
title_short	Tunable light and drug induced depletion of target proteins
title_full	Tunable light and drug induced depletion of target proteins
title_fullStr	Tunable light and drug induced depletion of target proteins
title_full_unstemmed	Tunable light and drug induced depletion of target proteins
title_sort	tunable light and drug induced depletion of target proteins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e0b9331a777b4a65a1b6e1126958bf30
work_keys_str_mv	AT wendeng tunablelightanddruginduceddepletionoftargetproteins AT jackabates tunablelightanddruginduceddepletionoftargetproteins AT haiwei tunablelightanddruginduceddepletionoftargetproteins AT michaeldbartoschek tunablelightanddruginduceddepletionoftargetproteins AT barbaraconradt tunablelightanddruginduceddepletionoftargetproteins AT heinrichleonhardt tunablelightanddruginduceddepletionoftargetproteins
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Tunable light and drug induced depletion of target proteins

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