Tunable light and drug induced depletion of target proteins

Methods to control protein degradation usually require prior genetic engineering of each specific protein of interest. Here the authors present a toolbox for targeted depletion of endogenous proteins in cells and organisms, which is based on light- and drug-controlled recombinant E3 ubiquitin ligase...

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Auteurs principaux: Wen Deng, Jack A. Bates, Hai Wei, Michael D. Bartoschek, Barbara Conradt, Heinrich Leonhardt
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/e0b9331a777b4a65a1b6e1126958bf30
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