C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study
Luting Nie,1,* Dandan Wei,2,* Pengling Liu,2 Li Zhang,2 Keliang Fan,2 Yu Song,1 Mian Wang,1 Lulu Wang,2 Qingqing Xu,2 Juan Wang,2 Xiaotian Liu,2 Linlin Li,2 Zhenxing Mao,2 Hui Huang,1 Chongjian Wang,2 Wenqian Huo1 1Department of Occupational and Environmental Health, College of Public Health, Zhengz...
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Dove Medical Press
2021
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oai:doaj.org-article:e0bda1dbdca3482baaffdf6d944770942021-12-02T10:37:31ZC-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study1178-7031https://doaj.org/article/e0bda1dbdca3482baaffdf6d944770942021-03-01T00:00:00Zhttps://www.dovepress.com/c-reactive-protein-mediates-the-effect-of-serum-progesterone-on-obesit-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Luting Nie,1,* Dandan Wei,2,* Pengling Liu,2 Li Zhang,2 Keliang Fan,2 Yu Song,1 Mian Wang,1 Lulu Wang,2 Qingqing Xu,2 Juan Wang,2 Xiaotian Liu,2 Linlin Li,2 Zhenxing Mao,2 Hui Huang,1 Chongjian Wang,2 Wenqian Huo1 1Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqian HuoDepartment of Occupational and Environmental Health Sciences, 100 Kexue Avenue, Zhengzhou, Henan, 450001, People’s Republic of ChinaTel +86 371 67781452Fax +86 371 67781868Email huowenqian@zzu.edu.cnPurpose: Studies of progesterone with obesity have been lacking, and no prior studies have investigated progesterone and C-reactive protein in rural natural populations. This study aimed to investigate the association of serum progesterone with obesity based on anthropometric parameters in Henan Rural Cohort, then further to explore the potential role of C-reactive protein in this association.Patients and Methods: A total of 4687 participants (2474 men and 2213 postmenopausal women) from the Henan Rural Cohort study were included. Logistic regression analysis, linear regression analysis, and restricted cubic splines were performed to estimate the relationships between progesterone, C-reactive protein, obesity, and obesity-related parameters. Mediation analysis was carried out to assess the intermediary role of C-reactive protein played in the association between progesterone and obesity.Results: After controlling for confounders, the odds ratios of obesity no matter how obesity was defined was associated with progesterone (P trend < 0.05). Moreover, progesterone was related to obesity-related parameters. Also, C-reactive protein increased with the elevation of progesterone, and C-reactive protein was associated with obesity no matter how obesity was defined (P trend < 0.001). Mediation analysis indicated that hsCRP had the mediating effects on the obesity, and the proportion of the effects were 15.35% and full mediating effect (defined by body mass index), 15.46% and 12.24% (defined by waist circumference), 19.14% and 12.12% (defined by waist-to-hip ratio), 23.81% and 15.09% (defined by waist-to-height ratio) for men and postmenopausal women, relatively.Conclusion: In the Chinese rural men and postmenopausal women population, progesterone and C-reactive protein are related to obesity. We firstly found C-reactive protein partly mediates the effect of progesterone on obesity, indicating that systemic inflammation played a critical role in the association.Keywords: sex hormone, obesity, C-reactive protein, mediation effectNie LWei DLiu PZhang LFan KSong YWang MWang LXu QWang JLiu XLi LMao ZHuang HWang CHuo WDove Medical Pressarticlesex hormoneobesityc-reactive proteinmediation effectPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 633-644 (2021) |
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EN |
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sex hormone obesity c-reactive protein mediation effect Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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sex hormone obesity c-reactive protein mediation effect Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Nie L Wei D Liu P Zhang L Fan K Song Y Wang M Wang L Xu Q Wang J Liu X Li L Mao Z Huang H Wang C Huo W C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study |
| description |
Luting Nie,1,* Dandan Wei,2,* Pengling Liu,2 Li Zhang,2 Keliang Fan,2 Yu Song,1 Mian Wang,1 Lulu Wang,2 Qingqing Xu,2 Juan Wang,2 Xiaotian Liu,2 Linlin Li,2 Zhenxing Mao,2 Hui Huang,1 Chongjian Wang,2 Wenqian Huo1 1Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqian HuoDepartment of Occupational and Environmental Health Sciences, 100 Kexue Avenue, Zhengzhou, Henan, 450001, People’s Republic of ChinaTel +86 371 67781452Fax +86 371 67781868Email huowenqian@zzu.edu.cnPurpose: Studies of progesterone with obesity have been lacking, and no prior studies have investigated progesterone and C-reactive protein in rural natural populations. This study aimed to investigate the association of serum progesterone with obesity based on anthropometric parameters in Henan Rural Cohort, then further to explore the potential role of C-reactive protein in this association.Patients and Methods: A total of 4687 participants (2474 men and 2213 postmenopausal women) from the Henan Rural Cohort study were included. Logistic regression analysis, linear regression analysis, and restricted cubic splines were performed to estimate the relationships between progesterone, C-reactive protein, obesity, and obesity-related parameters. Mediation analysis was carried out to assess the intermediary role of C-reactive protein played in the association between progesterone and obesity.Results: After controlling for confounders, the odds ratios of obesity no matter how obesity was defined was associated with progesterone (P trend < 0.05). Moreover, progesterone was related to obesity-related parameters. Also, C-reactive protein increased with the elevation of progesterone, and C-reactive protein was associated with obesity no matter how obesity was defined (P trend < 0.001). Mediation analysis indicated that hsCRP had the mediating effects on the obesity, and the proportion of the effects were 15.35% and full mediating effect (defined by body mass index), 15.46% and 12.24% (defined by waist circumference), 19.14% and 12.12% (defined by waist-to-hip ratio), 23.81% and 15.09% (defined by waist-to-height ratio) for men and postmenopausal women, relatively.Conclusion: In the Chinese rural men and postmenopausal women population, progesterone and C-reactive protein are related to obesity. We firstly found C-reactive protein partly mediates the effect of progesterone on obesity, indicating that systemic inflammation played a critical role in the association.Keywords: sex hormone, obesity, C-reactive protein, mediation effect |
| format |
article |
| author |
Nie L Wei D Liu P Zhang L Fan K Song Y Wang M Wang L Xu Q Wang J Liu X Li L Mao Z Huang H Wang C Huo W |
| author_facet |
Nie L Wei D Liu P Zhang L Fan K Song Y Wang M Wang L Xu Q Wang J Liu X Li L Mao Z Huang H Wang C Huo W |
| author_sort |
Nie L |
| title |
C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study |
| title_short |
C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study |
| title_full |
C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study |
| title_fullStr |
C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study |
| title_full_unstemmed |
C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study |
| title_sort |
c-reactive protein mediates the effect of serum progesterone on obesity for men and postmenopausal women in henan rural cohort study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/e0bda1dbdca3482baaffdf6d94477094 |
| work_keys_str_mv |
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