MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atheroscleroti...
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Nature Portfolio
2018
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oai:doaj.org-article:e0c0b515953e43daab3696ec2826dc832021-12-02T17:33:16ZMT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis10.1038/s41467-018-03351-42041-1723https://doaj.org/article/e0c0b515953e43daab3696ec2826dc832018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03351-4https://doaj.org/toc/2041-1723Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atherosclerotic lesions, which accelerates atherosclerosis.Cristina ClementeCristina RiusLaura Alonso-HerranzMara Martín-AlonsoÁngela PollánEmilio CamafeitaFernando MartínezRubén A. MotaVanessa NúñezCristina RodríguezMotoharu SeikiJosé Martínez-GonzálezVicente AndrésMercedes RicoteAlicia G. ArroyoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Cristina Clemente Cristina Rius Laura Alonso-Herranz Mara Martín-Alonso Ángela Pollán Emilio Camafeita Fernando Martínez Rubén A. Mota Vanessa Núñez Cristina Rodríguez Motoharu Seiki José Martínez-González Vicente Andrés Mercedes Ricote Alicia G. Arroyo MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| description |
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atherosclerotic lesions, which accelerates atherosclerosis. |
| format |
article |
| author |
Cristina Clemente Cristina Rius Laura Alonso-Herranz Mara Martín-Alonso Ángela Pollán Emilio Camafeita Fernando Martínez Rubén A. Mota Vanessa Núñez Cristina Rodríguez Motoharu Seiki José Martínez-González Vicente Andrés Mercedes Ricote Alicia G. Arroyo |
| author_facet |
Cristina Clemente Cristina Rius Laura Alonso-Herranz Mara Martín-Alonso Ángela Pollán Emilio Camafeita Fernando Martínez Rubén A. Mota Vanessa Núñez Cristina Rodríguez Motoharu Seiki José Martínez-González Vicente Andrés Mercedes Ricote Alicia G. Arroyo |
| author_sort |
Cristina Clemente |
| title |
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| title_short |
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| title_full |
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| title_fullStr |
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| title_full_unstemmed |
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| title_sort |
mt4-mmp deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e0c0b515953e43daab3696ec2826dc83 |
| work_keys_str_mv |
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| _version_ |
1718380032094633984 |