Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex

Patients treated for bilateral congenital cataracts provide a unique model to test the role of early visual input in shaping the development of the human cortex. Previous studies showed that brief early visual deprivation triggers long-lasting changes in the human visual cortex. However, it remains...

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Autores principales:	Yixuan Feng, Olivier Collignon, Daphne Maurer, Ke Yao, Xiaoqing Gao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	congenital cataracts early visual deprivation cortical thickness covariation functional connectivity magnetic resonance imaging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e0c13d3001c444ae90325ccbbb468ae8
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id	oai:doaj.org-article:e0c13d3001c444ae90325ccbbb468ae8
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spelling	oai:doaj.org-article:e0c13d3001c444ae90325ccbbb468ae82021-11-17T06:30:09ZBrief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex2296-858X10.3389/fmed.2021.752021https://doaj.org/article/e0c13d3001c444ae90325ccbbb468ae82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.752021/fullhttps://doaj.org/toc/2296-858XPatients treated for bilateral congenital cataracts provide a unique model to test the role of early visual input in shaping the development of the human cortex. Previous studies showed that brief early visual deprivation triggers long-lasting changes in the human visual cortex. However, it remains unknown if such changes interact with the development of other parts of the cortex. With high-resolution structural and resting-state fMRI images, we found changes in cortical thickness within, but not limited to, the visual cortex in adult patients, who experienced transient visual deprivation early in life as a result of congenital cataracts. Importantly, the covariation of cortical thickness across regions was also altered in the patients. The areas with altered cortical thickness in patients also showed differences in functional connectivity between patients and normally sighted controls. Together, the current findings suggest an impact of early visual deprivation on the interactive development of the human cortex.Yixuan FengYixuan FengOlivier CollignonOlivier CollignonDaphne MaurerDaphne MaurerKe YaoKe YaoXiaoqing GaoFrontiers Media S.A.articlecongenital cataractsearly visual deprivationcortical thickness covariationfunctional connectivitymagnetic resonance imagingMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	congenital cataracts early visual deprivation cortical thickness covariation functional connectivity magnetic resonance imaging Medicine (General) R5-920
spellingShingle	congenital cataracts early visual deprivation cortical thickness covariation functional connectivity magnetic resonance imaging Medicine (General) R5-920 Yixuan Feng Yixuan Feng Olivier Collignon Olivier Collignon Daphne Maurer Daphne Maurer Ke Yao Ke Yao Xiaoqing Gao Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex
description	Patients treated for bilateral congenital cataracts provide a unique model to test the role of early visual input in shaping the development of the human cortex. Previous studies showed that brief early visual deprivation triggers long-lasting changes in the human visual cortex. However, it remains unknown if such changes interact with the development of other parts of the cortex. With high-resolution structural and resting-state fMRI images, we found changes in cortical thickness within, but not limited to, the visual cortex in adult patients, who experienced transient visual deprivation early in life as a result of congenital cataracts. Importantly, the covariation of cortical thickness across regions was also altered in the patients. The areas with altered cortical thickness in patients also showed differences in functional connectivity between patients and normally sighted controls. Together, the current findings suggest an impact of early visual deprivation on the interactive development of the human cortex.
format	article
author	Yixuan Feng Yixuan Feng Olivier Collignon Olivier Collignon Daphne Maurer Daphne Maurer Ke Yao Ke Yao Xiaoqing Gao
author_facet	Yixuan Feng Yixuan Feng Olivier Collignon Olivier Collignon Daphne Maurer Daphne Maurer Ke Yao Ke Yao Xiaoqing Gao
author_sort	Yixuan Feng
title	Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex
title_short	Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex
title_full	Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex
title_fullStr	Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex
title_full_unstemmed	Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex
title_sort	brief postnatal visual deprivation triggers long-lasting interactive structural and functional reorganization of the human cortex
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e0c13d3001c444ae90325ccbbb468ae8
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Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex

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