Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice.
<h4>Background</h4>Daily variations in lipid concentrations in both gut lumen and blood are detected by specific sensors located in the gastrointestinal tract and in specialized central areas. Deregulation of the lipid sensors could be partly involved in the dysfunction of glucose homeos...
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2011
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oai:doaj.org-article:e0c2c0d1e4794896a62dc7264e2ea5862021-11-18T06:51:58ZLipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice.1932-620310.1371/journal.pone.0021184https://doaj.org/article/e0c2c0d1e4794896a62dc7264e2ea5862011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21698161/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Daily variations in lipid concentrations in both gut lumen and blood are detected by specific sensors located in the gastrointestinal tract and in specialized central areas. Deregulation of the lipid sensors could be partly involved in the dysfunction of glucose homeostasis. The study aimed at comparing the effect of Medialipid (ML) overload on insulin secretion and sensitivity when administered either through the intestine or the carotid artery in mice.<h4>Methodology/principal findings</h4>An indwelling intragastric or intracarotid catheter was installed in mice and ML or an isocaloric solution was infused over 24 hours. Glucose and insulin tolerance and vagus nerve activity were assessed. Some mice were treated daily for one week with the anti-lipid peroxidation agent aminoguanidine prior to the infusions and tests. The intestinal but not the intracarotid infusion of ML led to glucose and insulin intolerance when compared with controls. The intestinal ML overload induced lipid accumulation and increased lipid peroxidation as assessed by increased malondialdehyde production within both jejunum and duodenum. These effects were associated with the concomitant deregulation of vagus nerve. Administration of aminoguanidine protected against the effects of lipid overload and normalized glucose homeostasis and vagus nerve activity.<h4>Conclusions/significance</h4>Lipid overload within the intestine led to deregulation of gastrointestinal lipid sensing that in turn impaired glucose homeostasis through changes in autonomic nervous system activity.Matteo SerinoAurélie WagetNicolas MarsollierMyriam MasseboeufGaëlle PayrosCatherine KabaniJessica DenomAmélie LacombeJean-Claude ThiersAnne Negre-SalvayreSerge LuquetRémy BurcelinCéline Cruciani-GuglielmacciChristophe MagnanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21184 (2011) |
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Medicine R Science Q Matteo Serino Aurélie Waget Nicolas Marsollier Myriam Masseboeuf Gaëlle Payros Catherine Kabani Jessica Denom Amélie Lacombe Jean-Claude Thiers Anne Negre-Salvayre Serge Luquet Rémy Burcelin Céline Cruciani-Guglielmacci Christophe Magnan Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| description |
<h4>Background</h4>Daily variations in lipid concentrations in both gut lumen and blood are detected by specific sensors located in the gastrointestinal tract and in specialized central areas. Deregulation of the lipid sensors could be partly involved in the dysfunction of glucose homeostasis. The study aimed at comparing the effect of Medialipid (ML) overload on insulin secretion and sensitivity when administered either through the intestine or the carotid artery in mice.<h4>Methodology/principal findings</h4>An indwelling intragastric or intracarotid catheter was installed in mice and ML or an isocaloric solution was infused over 24 hours. Glucose and insulin tolerance and vagus nerve activity were assessed. Some mice were treated daily for one week with the anti-lipid peroxidation agent aminoguanidine prior to the infusions and tests. The intestinal but not the intracarotid infusion of ML led to glucose and insulin intolerance when compared with controls. The intestinal ML overload induced lipid accumulation and increased lipid peroxidation as assessed by increased malondialdehyde production within both jejunum and duodenum. These effects were associated with the concomitant deregulation of vagus nerve. Administration of aminoguanidine protected against the effects of lipid overload and normalized glucose homeostasis and vagus nerve activity.<h4>Conclusions/significance</h4>Lipid overload within the intestine led to deregulation of gastrointestinal lipid sensing that in turn impaired glucose homeostasis through changes in autonomic nervous system activity. |
| format |
article |
| author |
Matteo Serino Aurélie Waget Nicolas Marsollier Myriam Masseboeuf Gaëlle Payros Catherine Kabani Jessica Denom Amélie Lacombe Jean-Claude Thiers Anne Negre-Salvayre Serge Luquet Rémy Burcelin Céline Cruciani-Guglielmacci Christophe Magnan |
| author_facet |
Matteo Serino Aurélie Waget Nicolas Marsollier Myriam Masseboeuf Gaëlle Payros Catherine Kabani Jessica Denom Amélie Lacombe Jean-Claude Thiers Anne Negre-Salvayre Serge Luquet Rémy Burcelin Céline Cruciani-Guglielmacci Christophe Magnan |
| author_sort |
Matteo Serino |
| title |
Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| title_short |
Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| title_full |
Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| title_fullStr |
Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| title_full_unstemmed |
Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| title_sort |
lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/e0c2c0d1e4794896a62dc7264e2ea586 |
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