Synthetic promoters to induce immune-effectors into the tumor microenvironment

Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose that this method can circumvent off-target toxic effe...

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Autores principales:	Yariv Greenshpan, Omri Sharabi, Aner Ottolenghi, Avishag Cahana, Kiran Kundu, Ksenia M. Yegodayev, Moshe Elkabets, Roi Gazit, Angel Porgador
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e0c47efecb0d4ae69091de751e705b6f
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spelling	oai:doaj.org-article:e0c47efecb0d4ae69091de751e705b6f2021-12-02T13:57:58ZSynthetic promoters to induce immune-effectors into the tumor microenvironment10.1038/s42003-021-01664-72399-3642https://doaj.org/article/e0c47efecb0d4ae69091de751e705b6f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01664-7https://doaj.org/toc/2399-3642Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose that this method can circumvent off-target toxic effects via specific expression of the CAR in the tumor microenvironment.Yariv GreenshpanOmri SharabiAner OttolenghiAvishag CahanaKiran KunduKsenia M. YegodayevMoshe ElkabetsRoi GazitAngel PorgadorNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yariv Greenshpan Omri Sharabi Aner Ottolenghi Avishag Cahana Kiran Kundu Ksenia M. Yegodayev Moshe Elkabets Roi Gazit Angel Porgador Synthetic promoters to induce immune-effectors into the tumor microenvironment
description	Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose that this method can circumvent off-target toxic effects via specific expression of the CAR in the tumor microenvironment.
format	article
author	Yariv Greenshpan Omri Sharabi Aner Ottolenghi Avishag Cahana Kiran Kundu Ksenia M. Yegodayev Moshe Elkabets Roi Gazit Angel Porgador
author_facet	Yariv Greenshpan Omri Sharabi Aner Ottolenghi Avishag Cahana Kiran Kundu Ksenia M. Yegodayev Moshe Elkabets Roi Gazit Angel Porgador
author_sort	Yariv Greenshpan
title	Synthetic promoters to induce immune-effectors into the tumor microenvironment
title_short	Synthetic promoters to induce immune-effectors into the tumor microenvironment
title_full	Synthetic promoters to induce immune-effectors into the tumor microenvironment
title_fullStr	Synthetic promoters to induce immune-effectors into the tumor microenvironment
title_full_unstemmed	Synthetic promoters to induce immune-effectors into the tumor microenvironment
title_sort	synthetic promoters to induce immune-effectors into the tumor microenvironment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0c47efecb0d4ae69091de751e705b6f
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Synthetic promoters to induce immune-effectors into the tumor microenvironment

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