First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods

Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all metazoans, but open questions existed on its prese...

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Autores principales:	Vittoria Roncalli, Chiara Lauritano, Ylenia Carotenuto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	zooplankton natural products antioxidant transcriptome mining Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e0c651665be4495ea780da9ead3d940e
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spelling	oai:doaj.org-article:e0c651665be4495ea780da9ead3d940e2021-11-25T18:13:04ZFirst Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods10.3390/md191106471660-3397https://doaj.org/article/e0c651665be4495ea780da9ead3d940e2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/647https://doaj.org/toc/1660-3397Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all metazoans, but open questions existed on its presence among arthropods. Here, using an in silico workflow, we report a single OvoA gene in marine arthropods including copepods, decapods, and amphipods. Phylogenetic analyses indicated that OvoA from marine arthropods separated from the other marine phyla (e.g., Porifera, Mollusca) and divided into two separate branches, suggesting a possible divergence through evolution. In the copepod <i>Calanus finmarchicus</i>, we suggest that OvoA has a defense role in oxidative stress as shown by its high expression in response to a toxic diet and during the copepodite stage, a developmental stage that includes significant morphological changes. Overall, the results of our study open possibilities for the use of OvoA as a biomarker of stress in copepods and possibly also for other marine holozooplankters. The finding of OvoA in copepods is also promising for the drug discovery field, suggesting the possibility of using copepods as a new source of bioactive compounds to be tested in the marine biotechnological sector.Vittoria RoncalliChiara LauritanoYlenia CarotenutoMDPI AGarticlezooplanktonnatural productsantioxidanttranscriptome miningBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 647, p 647 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	zooplankton natural products antioxidant transcriptome mining Biology (General) QH301-705.5
spellingShingle	zooplankton natural products antioxidant transcriptome mining Biology (General) QH301-705.5 Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
description	Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all metazoans, but open questions existed on its presence among arthropods. Here, using an in silico workflow, we report a single OvoA gene in marine arthropods including copepods, decapods, and amphipods. Phylogenetic analyses indicated that OvoA from marine arthropods separated from the other marine phyla (e.g., Porifera, Mollusca) and divided into two separate branches, suggesting a possible divergence through evolution. In the copepod <i>Calanus finmarchicus</i>, we suggest that OvoA has a defense role in oxidative stress as shown by its high expression in response to a toxic diet and during the copepodite stage, a developmental stage that includes significant morphological changes. Overall, the results of our study open possibilities for the use of OvoA as a biomarker of stress in copepods and possibly also for other marine holozooplankters. The finding of OvoA in copepods is also promising for the drug discovery field, suggesting the possibility of using copepods as a new source of bioactive compounds to be tested in the marine biotechnological sector.
format	article
author	Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto
author_facet	Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto
author_sort	Vittoria Roncalli
title	First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
title_short	First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
title_full	First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
title_fullStr	First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
title_full_unstemmed	First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
title_sort	first report of ovoa gene in marine arthropods: a new candidate stress biomarker in copepods
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0c651665be4495ea780da9ead3d940e
work_keys_str_mv	AT vittoriaroncalli firstreportofovoageneinmarinearthropodsanewcandidatestressbiomarkerincopepods AT chiaralauritano firstreportofovoageneinmarinearthropodsanewcandidatestressbiomarkerincopepods AT yleniacarotenuto firstreportofovoageneinmarinearthropodsanewcandidatestressbiomarkerincopepods
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First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods

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