Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice

Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, <i>Smallantchus s...

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Autores principales:	Sylwia Wośko, Anna Serefko, Aleksandra Szopa, Sylwia Kardaś, Jarosław Widelski, Tomasz Mroczek, Ewelina Rostkowska, Jolanta Szymańska, Ewa Poleszak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Yacon (<i>Smallantchus sonchifolius</i>) imipramine fluoxetine reboxetine forced swim test mice Science Q
Acceso en línea:	https://doaj.org/article/e0c6a62f4ab14a9fb2ffdbf6779981b9
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spelling	oai:doaj.org-article:e0c6a62f4ab14a9fb2ffdbf6779981b92021-11-25T18:10:25ZInfluence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice10.3390/life111111172075-1729https://doaj.org/article/e0c6a62f4ab14a9fb2ffdbf6779981b92021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1117https://doaj.org/toc/2075-1729Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, <i>Smallantchus sonchifolius</i>, belongs to plants with numerous health-beneficial properties. Yacon-based products are regarded as a functional food. In our study, we attempted to check whether administration of Yacon tuber extract would have an antidepressant effect in the forced swim test (FST) in mice and whether its intake could influence the activity of conventional antidepressant drugs with different mechanisms of action, i.e., imipramine hydrochloride, fluoxetine hydrochloride, and reboxetine mesylate. The spontaneous locomotor activity of the tested mice was also investigated to eliminate any false-positive results. We demonstrated that an intragastric administration of the Yacon tuber extract at a dose of 100 mg/kg induced the antidepressant-like behavior in the FST in mice and that a combined administration of the sub-effective doses of the Yacon extract (50 mg/kg) with imipramine hydrochloride (7.5 mg/kg), fluoxetine hydrochloride (20 mg/kg), or reboxetine mesylate (5 mg/kg) significantly reduced the immobility time of animals in this behavioral test. The obtained results were not affected by the increased locomotor activity of the tested subjects. In conclusion, our findings suggest that Yacon tuber extract is promising as an alternative mood-improving product since it possesses an antidepressant potential and it can acts synergistically with conventional antidepressant drugs.Sylwia WośkoAnna SerefkoAleksandra SzopaSylwia KardaśJarosław WidelskiTomasz MroczekEwelina RostkowskaJolanta SzymańskaEwa PoleszakMDPI AGarticleYacon (<i>Smallantchus sonchifolius</i>)imipraminefluoxetinereboxetineforced swim testmiceScienceQENLife, Vol 11, Iss 1117, p 1117 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Yacon (<i>Smallantchus sonchifolius</i>) imipramine fluoxetine reboxetine forced swim test mice Science Q
spellingShingle	Yacon (<i>Smallantchus sonchifolius</i>) imipramine fluoxetine reboxetine forced swim test mice Science Q Sylwia Wośko Anna Serefko Aleksandra Szopa Sylwia Kardaś Jarosław Widelski Tomasz Mroczek Ewelina Rostkowska Jolanta Szymańska Ewa Poleszak Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
description	Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, <i>Smallantchus sonchifolius</i>, belongs to plants with numerous health-beneficial properties. Yacon-based products are regarded as a functional food. In our study, we attempted to check whether administration of Yacon tuber extract would have an antidepressant effect in the forced swim test (FST) in mice and whether its intake could influence the activity of conventional antidepressant drugs with different mechanisms of action, i.e., imipramine hydrochloride, fluoxetine hydrochloride, and reboxetine mesylate. The spontaneous locomotor activity of the tested mice was also investigated to eliminate any false-positive results. We demonstrated that an intragastric administration of the Yacon tuber extract at a dose of 100 mg/kg induced the antidepressant-like behavior in the FST in mice and that a combined administration of the sub-effective doses of the Yacon extract (50 mg/kg) with imipramine hydrochloride (7.5 mg/kg), fluoxetine hydrochloride (20 mg/kg), or reboxetine mesylate (5 mg/kg) significantly reduced the immobility time of animals in this behavioral test. The obtained results were not affected by the increased locomotor activity of the tested subjects. In conclusion, our findings suggest that Yacon tuber extract is promising as an alternative mood-improving product since it possesses an antidepressant potential and it can acts synergistically with conventional antidepressant drugs.
format	article
author	Sylwia Wośko Anna Serefko Aleksandra Szopa Sylwia Kardaś Jarosław Widelski Tomasz Mroczek Ewelina Rostkowska Jolanta Szymańska Ewa Poleszak
author_facet	Sylwia Wośko Anna Serefko Aleksandra Szopa Sylwia Kardaś Jarosław Widelski Tomasz Mroczek Ewelina Rostkowska Jolanta Szymańska Ewa Poleszak
author_sort	Sylwia Wośko
title	Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
title_short	Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
title_full	Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
title_fullStr	Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
title_full_unstemmed	Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
title_sort	influence of <i>smallanthus sonchifolius</i> (yacon) on the activity of antidepressant drugs in mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0c6a62f4ab14a9fb2ffdbf6779981b9
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Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice

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