Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture, in mice and in human studies.

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Autores principales:	Nicholas D. Walter, Sarah E. M. Born, Gregory T. Robertson, Matthew Reichlen, Christian Dide-Agossou, Victoria A. Ektnitphong, Karen Rossmassler, Michelle E. Ramey, Allison A. Bauman, Victor Ozols, Shelby C. Bearrows, Gary Schoolnik, Gregory Dolganov, Benjamin Garcia, Emmanuel Musisi, William Worodria, Laurence Huang, J. Lucian Davis, Nhung V. Nguyen, Hung V. Nguyen, Anh T. V. Nguyen, Ha Phan, Carol Wilusz, Brendan K. Podell, N’ Dira Sanoussi, Bouke C. de Jong, Corinne S. Merle, Dissou Affolabi, Helen McIlleron, Maria Garcia-Cremades, Ekaterina Maidji, Franceen Eshun-Wilson, Brandon Aguilar-Rodriguez, Dhuvarakesh Karthikeyan, Khisimuzi Mdluli, Cathy Bansbach, Anne J. Lenaerts, Radojka M. Savic, Payam Nahid, Joshua J. Vásquez, Martin I. Voskuil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb7
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spelling	oai:doaj.org-article:e0c6c2c659ca434dbad834a1759cfbb72021-12-02T15:52:23ZMycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens10.1038/s41467-021-22833-62041-1723https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22833-6https://doaj.org/toc/2041-1723It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture, in mice and in human studies.Nicholas D. WalterSarah E. M. BornGregory T. RobertsonMatthew ReichlenChristian Dide-AgossouVictoria A. EktnitphongKaren RossmasslerMichelle E. RameyAllison A. BaumanVictor OzolsShelby C. BearrowsGary SchoolnikGregory DolganovBenjamin GarciaEmmanuel MusisiWilliam WorodriaLaurence HuangJ. Lucian DavisNhung V. NguyenHung V. NguyenAnh T. V. NguyenHa PhanCarol WiluszBrendan K. PodellN’ Dira SanoussiBouke C. de JongCorinne S. MerleDissou AffolabiHelen McIlleronMaria Garcia-CremadesEkaterina MaidjiFranceen Eshun-WilsonBrandon Aguilar-RodriguezDhuvarakesh KarthikeyanKhisimuzi MdluliCathy BansbachAnne J. LenaertsRadojka M. SavicPayam NahidJoshua J. VásquezMartin I. VoskuilNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas D. Walter Sarah E. M. Born Gregory T. Robertson Matthew Reichlen Christian Dide-Agossou Victoria A. Ektnitphong Karen Rossmassler Michelle E. Ramey Allison A. Bauman Victor Ozols Shelby C. Bearrows Gary Schoolnik Gregory Dolganov Benjamin Garcia Emmanuel Musisi William Worodria Laurence Huang J. Lucian Davis Nhung V. Nguyen Hung V. Nguyen Anh T. V. Nguyen Ha Phan Carol Wilusz Brendan K. Podell N’ Dira Sanoussi Bouke C. de Jong Corinne S. Merle Dissou Affolabi Helen McIlleron Maria Garcia-Cremades Ekaterina Maidji Franceen Eshun-Wilson Brandon Aguilar-Rodriguez Dhuvarakesh Karthikeyan Khisimuzi Mdluli Cathy Bansbach Anne J. Lenaerts Radojka M. Savic Payam Nahid Joshua J. Vásquez Martin I. Voskuil Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
description	It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture, in mice and in human studies.
format	article
author	Nicholas D. Walter Sarah E. M. Born Gregory T. Robertson Matthew Reichlen Christian Dide-Agossou Victoria A. Ektnitphong Karen Rossmassler Michelle E. Ramey Allison A. Bauman Victor Ozols Shelby C. Bearrows Gary Schoolnik Gregory Dolganov Benjamin Garcia Emmanuel Musisi William Worodria Laurence Huang J. Lucian Davis Nhung V. Nguyen Hung V. Nguyen Anh T. V. Nguyen Ha Phan Carol Wilusz Brendan K. Podell N’ Dira Sanoussi Bouke C. de Jong Corinne S. Merle Dissou Affolabi Helen McIlleron Maria Garcia-Cremades Ekaterina Maidji Franceen Eshun-Wilson Brandon Aguilar-Rodriguez Dhuvarakesh Karthikeyan Khisimuzi Mdluli Cathy Bansbach Anne J. Lenaerts Radojka M. Savic Payam Nahid Joshua J. Vásquez Martin I. Voskuil
author_facet	Nicholas D. Walter Sarah E. M. Born Gregory T. Robertson Matthew Reichlen Christian Dide-Agossou Victoria A. Ektnitphong Karen Rossmassler Michelle E. Ramey Allison A. Bauman Victor Ozols Shelby C. Bearrows Gary Schoolnik Gregory Dolganov Benjamin Garcia Emmanuel Musisi William Worodria Laurence Huang J. Lucian Davis Nhung V. Nguyen Hung V. Nguyen Anh T. V. Nguyen Ha Phan Carol Wilusz Brendan K. Podell N’ Dira Sanoussi Bouke C. de Jong Corinne S. Merle Dissou Affolabi Helen McIlleron Maria Garcia-Cremades Ekaterina Maidji Franceen Eshun-Wilson Brandon Aguilar-Rodriguez Dhuvarakesh Karthikeyan Khisimuzi Mdluli Cathy Bansbach Anne J. Lenaerts Radojka M. Savic Payam Nahid Joshua J. Vásquez Martin I. Voskuil
author_sort	Nicholas D. Walter
title	Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
title_short	Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
title_full	Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
title_fullStr	Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
title_full_unstemmed	Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
title_sort	mycobacterium tuberculosis precursor rrna as a measure of treatment-shortening activity of drugs and regimens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb7
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Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

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