Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer

Introduction The current study examined the clinical impacts of phosphatase and tensin (PTEN) expression in prostate cancer (PCa) using immunohistochemistry. Methods 50 patients with mean age of 66.4±7.3 years who had undergone prostatectomy surgery with the diagnosis of PCa, were enrolled in the...

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Autores principales:	Mojtaba Saadati, Saeed Tamehri, Mohsen Pour Kamali, Diana Taheri
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2021
Materias:	prostate cancer phosphatase tensin prostate-specific antigen biochemical recurrence Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/e0c7b77008084beb910840814657d8ff
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spelling	oai:doaj.org-article:e0c7b77008084beb910840814657d8ff2021-11-27T07:09:00ZPhosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer10.22034/TRU.2021.276823.10622717-042Xhttps://doaj.org/article/e0c7b77008084beb910840814657d8ff2021-04-01T00:00:00Zhttps://www.transresurology.com/article_128689.htmlhttps://doaj.org/toc/2717-042XIntroduction The current study examined the clinical impacts of phosphatase and tensin (PTEN) expression in prostate cancer (PCa) using immunohistochemistry. Methods 50 patients with mean age of 66.4±7.3 years who had undergone prostatectomy surgery with the diagnosis of PCa, were enrolled in the study. We collected 50 paraffin blocks from the malignant part and 50 paraffin blocks from the healthy part of each patient’s prostate. We considered malignant and healthy parts as the case and the control, respectively. Clinical and pathological information of the patients were gathered and their associations with PTEN status were assessed using odds ratios (ORs) analysis. Results The significant associations between tumor stage, perivascular invasion, perineural invasion, marginal involvement, extraprostatic extension, and biochemical recurrence (as assed by post-surgical prostate-specific antigen (PSA)) and PTEN expression were detected. For patients negative for PTEN, the odds ratio of the higher stage, perivascular invasion, perineural invasion, marginal involvement, and extraprostatic extension in comparison to patients positive for PTEN were estimated 7.5 (95%CI: 2.01,27.86), (95%CI: 1.65-25.57), 7.8 (95%CI:1.54-40.09), 9.78 (95%CI:2.33-41.08), and 4.84 (95%CI:1.07-21.84), respectively. Concerning biochemical recurrence, ORs was calculated 0.30 (95%CI:0.09-1.02) for PTEN positive patients compare to PTEN negative patients. Conclusions Since PTEN loss was associated with features of aggressive PCa, it can be concluded that loss of PTEN would lead to more aggressive PCa and thereby, lower clinical outcomes.Mojtaba Saadati Saeed Tamehri Mohsen Pour Kamali Diana Taheri Urology Research Centerarticleprostate cancerphosphatasetensinprostate-specific antigenbiochemical recurrenceDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 3, Iss 1, Pp 32-37 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer phosphatase tensin prostate-specific antigen biochemical recurrence Diseases of the genitourinary system. Urology RC870-923
spellingShingle	prostate cancer phosphatase tensin prostate-specific antigen biochemical recurrence Diseases of the genitourinary system. Urology RC870-923 Mojtaba Saadati Saeed Tamehri Mohsen Pour Kamali Diana Taheri Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
description	Introduction The current study examined the clinical impacts of phosphatase and tensin (PTEN) expression in prostate cancer (PCa) using immunohistochemistry. Methods 50 patients with mean age of 66.4±7.3 years who had undergone prostatectomy surgery with the diagnosis of PCa, were enrolled in the study. We collected 50 paraffin blocks from the malignant part and 50 paraffin blocks from the healthy part of each patient’s prostate. We considered malignant and healthy parts as the case and the control, respectively. Clinical and pathological information of the patients were gathered and their associations with PTEN status were assessed using odds ratios (ORs) analysis. Results The significant associations between tumor stage, perivascular invasion, perineural invasion, marginal involvement, extraprostatic extension, and biochemical recurrence (as assed by post-surgical prostate-specific antigen (PSA)) and PTEN expression were detected. For patients negative for PTEN, the odds ratio of the higher stage, perivascular invasion, perineural invasion, marginal involvement, and extraprostatic extension in comparison to patients positive for PTEN were estimated 7.5 (95%CI: 2.01,27.86), (95%CI: 1.65-25.57), 7.8 (95%CI:1.54-40.09), 9.78 (95%CI:2.33-41.08), and 4.84 (95%CI:1.07-21.84), respectively. Concerning biochemical recurrence, ORs was calculated 0.30 (95%CI:0.09-1.02) for PTEN positive patients compare to PTEN negative patients. Conclusions Since PTEN loss was associated with features of aggressive PCa, it can be concluded that loss of PTEN would lead to more aggressive PCa and thereby, lower clinical outcomes.
format	article
author	Mojtaba Saadati Saeed Tamehri Mohsen Pour Kamali Diana Taheri
author_facet	Mojtaba Saadati Saeed Tamehri Mohsen Pour Kamali Diana Taheri
author_sort	Mojtaba Saadati
title	Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
title_short	Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
title_full	Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
title_fullStr	Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
title_full_unstemmed	Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
title_sort	phosphatase and tensin gene associated with features of aggressive prostate cancer
publisher	Urology Research Center
publishDate	2021
url	https://doaj.org/article/e0c7b77008084beb910840814657d8ff
work_keys_str_mv	AT mojtabasaadati phosphataseandtensingeneassociatedwithfeaturesofaggressiveprostatecancer AT saeedtamehri phosphataseandtensingeneassociatedwithfeaturesofaggressiveprostatecancer AT mohsenpourkamali phosphataseandtensingeneassociatedwithfeaturesofaggressiveprostatecancer AT dianataheri phosphataseandtensingeneassociatedwithfeaturesofaggressiveprostatecancer
_version_	1718409198147993600

Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer

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