Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution

Background: Conceived of as the “silver lining” of the dark cloud of the coronavirus disease 2019 (COVID-19) pandemic, lessons taught by this catastrophe should be leveraged by medical authorities and policy makers to optimize health care globally. A major lesson is that resilient health systems sho...

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Autores principales:	Maria V. Deligiorgi, Gerasimos Siasos, Lampros Vakkas, Dimitrios T. Trafalis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 thyroid cancer differentiated thyroid cancer COVID-19 severity inflammation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e0ce54899c6a499c9b9a0ee9ef18bf82
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spelling	oai:doaj.org-article:e0ce54899c6a499c9b9a0ee9ef18bf822021-11-25T17:03:57ZCharting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution10.3390/cancers132257852072-6694https://doaj.org/article/e0ce54899c6a499c9b9a0ee9ef18bf822021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5785https://doaj.org/toc/2072-6694Background: Conceived of as the “silver lining” of the dark cloud of the coronavirus disease 2019 (COVID-19) pandemic, lessons taught by this catastrophe should be leveraged by medical authorities and policy makers to optimize health care globally. A major lesson is that resilient health systems should absorb sudden shocks incited by overwhelming health emergencies without compromising the continuum of care of chronic diseases, especially of cancer. Methods: The present review dissects the association between COVID-19 and thyroid cancer (TC), especially with differentiated TC (DTC), focusing on available data, knowledge gaps, current challenges, and future perspectives. Results: Obesity has been incriminated in terms of both COVID-19 severity and a rising incidence of TC, especially of DTC. The current conceptualization of the pathophysiological landscape of COVID-19–(D)TC association implicates an interplay between obesity, inflammation, immunity, and oxidative stress. Whether COVID-19 could aggravate the health burden posed by (D)TC or vice versa has yet to be clarified. Improved understanding and harnessing of the pathophysiological landscape of the COVID-19–(D)TC association will empower a mechanism-guided, safe, evidence-based, and risk-stratified management of (D)TC in the COVID-19 era and beyond. Conclusion: A multidisciplinary patient-centered decision-making will ensure high-quality (D)TC care for patients, with or without COVID-19.Maria V. DeligiorgiGerasimos SiasosLampros VakkasDimitrios T. TrafalisMDPI AGarticleCOVID-19SARS-CoV-2thyroid cancerdifferentiated thyroid cancerCOVID-19 severityinflammationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5785, p 5785 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 thyroid cancer differentiated thyroid cancer COVID-19 severity inflammation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	COVID-19 SARS-CoV-2 thyroid cancer differentiated thyroid cancer COVID-19 severity inflammation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Maria V. Deligiorgi Gerasimos Siasos Lampros Vakkas Dimitrios T. Trafalis Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution
description	Background: Conceived of as the “silver lining” of the dark cloud of the coronavirus disease 2019 (COVID-19) pandemic, lessons taught by this catastrophe should be leveraged by medical authorities and policy makers to optimize health care globally. A major lesson is that resilient health systems should absorb sudden shocks incited by overwhelming health emergencies without compromising the continuum of care of chronic diseases, especially of cancer. Methods: The present review dissects the association between COVID-19 and thyroid cancer (TC), especially with differentiated TC (DTC), focusing on available data, knowledge gaps, current challenges, and future perspectives. Results: Obesity has been incriminated in terms of both COVID-19 severity and a rising incidence of TC, especially of DTC. The current conceptualization of the pathophysiological landscape of COVID-19–(D)TC association implicates an interplay between obesity, inflammation, immunity, and oxidative stress. Whether COVID-19 could aggravate the health burden posed by (D)TC or vice versa has yet to be clarified. Improved understanding and harnessing of the pathophysiological landscape of the COVID-19–(D)TC association will empower a mechanism-guided, safe, evidence-based, and risk-stratified management of (D)TC in the COVID-19 era and beyond. Conclusion: A multidisciplinary patient-centered decision-making will ensure high-quality (D)TC care for patients, with or without COVID-19.
format	article
author	Maria V. Deligiorgi Gerasimos Siasos Lampros Vakkas Dimitrios T. Trafalis
author_facet	Maria V. Deligiorgi Gerasimos Siasos Lampros Vakkas Dimitrios T. Trafalis
author_sort	Maria V. Deligiorgi
title	Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution
title_short	Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution
title_full	Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution
title_fullStr	Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution
title_full_unstemmed	Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution
title_sort	charting the unknown association of covid-19 with thyroid cancer, focusing on differentiated thyroid cancer: a call for caution
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0ce54899c6a499c9b9a0ee9ef18bf82
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Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution

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