Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer

The involvement of axillary lymph nodes is one of the most important prognostic factors, significantly affecting the treatment strategy for early breast cancer (BC). The risk of axillary lymph node metastases depends directly on a number of factors (age of women, size of tumor, presence of lymphovas...

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Autores principales:	Irina V. Kolyadina, Tatiana Yu. Danzanova, Svetlana V. Khokhlova, Oksana P. Trofimova, Ekaterina V. Kovaleva, Valerii V. Rodionov, Irina V. Poddubnaya
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2020
Materias:	breast cancer axillary lymph nodes metastases ultrasound assessment of the status of regional lymph nodes sentinel lymph node biopsy locoregional treatment of early breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e0d0f965dba7427899ab6e589e1caaa9
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spelling	oai:doaj.org-article:e0d0f965dba7427899ab6e589e1caaa92021-11-30T17:03:34ZModern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer1815-14341815-144210.26442/18151434.2020.1.200018https://doaj.org/article/e0d0f965dba7427899ab6e589e1caaa92020-05-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/34171/22584https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442The involvement of axillary lymph nodes is one of the most important prognostic factors, significantly affecting the treatment strategy for early breast cancer (BC). The risk of axillary lymph node metastases depends directly on a number of factors (age of women, size of tumor, presence of lymphovascular invasion and biological characteristics of cancer). The evaluation of regional lymph node status in patients with early BC includes the clinical examination of regional zones and the ultrasound study (US), using these methods can help to study lymph nodes shape, borders, margins and structure. The sensitivity of ultrasound in the evaluation of regional lymph nodes status directly depends on the biological subtype of the tumor; the minimum level of ultrasound sensitivity in the evaluation of lymph nodes status is detected for luminal HER2-negative cancer (less than 40%), and maximum sensitivity is detected for triple negative and HER2-positive subtypes (6871%). Clinical examination and modern ultrasound are the most accessible methods for the evaluation of regional lymph nodes status, but the possibility to misjudge metastatic process can be detected in 1/4 of patients. Verification of the diagnosis in the preoperative phase (fine-needle aspiration biopsy/core-needle biopsy under ultrasound guidance) allows minimize the number of errors for the regional staging. The sentinel lymph node biopsy (SLNB) is the gold standard of regional treatment in patients with early stage BC, nowadays. The randomized trials (NSABP B-32, ACOSOG q0011) show the safety of recession of performing regional lymph node dissection in favor of SLNB not only in case of clinically negative lymph nodes, but also in patients with metastases in 2 sentinel lymph nodes, upon condition that organ-conservative treatment and subsequent radiation therapy will be used. High-quality regional staging, the choice of the therapeutic algorithm in accordance with the biological characteristics of carcinoma, the application of the most effective modern drug regimes, the optimal radiation therapy allow not only minimize the extent of surgery, but also achieve high long-term survival results, provide excellent functional results and high quality of life in patients with the involvement of axillary lymph nodes.Irina V. KolyadinaTatiana Yu. DanzanovaSvetlana V. KhokhlovaOksana P. TrofimovaEkaterina V. KovalevaValerii V. RodionovIrina V. PoddubnayaIP Habib O.N.articlebreast canceraxillary lymph nodes metastasesultrasound assessment of the status of regional lymph nodessentinel lymph node biopsylocoregional treatment of early breast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 1, Pp 46-52 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	breast cancer axillary lymph nodes metastases ultrasound assessment of the status of regional lymph nodes sentinel lymph node biopsy locoregional treatment of early breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer axillary lymph nodes metastases ultrasound assessment of the status of regional lymph nodes sentinel lymph node biopsy locoregional treatment of early breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Irina V. Kolyadina Tatiana Yu. Danzanova Svetlana V. Khokhlova Oksana P. Trofimova Ekaterina V. Kovaleva Valerii V. Rodionov Irina V. Poddubnaya Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
description	The involvement of axillary lymph nodes is one of the most important prognostic factors, significantly affecting the treatment strategy for early breast cancer (BC). The risk of axillary lymph node metastases depends directly on a number of factors (age of women, size of tumor, presence of lymphovascular invasion and biological characteristics of cancer). The evaluation of regional lymph node status in patients with early BC includes the clinical examination of regional zones and the ultrasound study (US), using these methods can help to study lymph nodes shape, borders, margins and structure. The sensitivity of ultrasound in the evaluation of regional lymph nodes status directly depends on the biological subtype of the tumor; the minimum level of ultrasound sensitivity in the evaluation of lymph nodes status is detected for luminal HER2-negative cancer (less than 40%), and maximum sensitivity is detected for triple negative and HER2-positive subtypes (6871%). Clinical examination and modern ultrasound are the most accessible methods for the evaluation of regional lymph nodes status, but the possibility to misjudge metastatic process can be detected in 1/4 of patients. Verification of the diagnosis in the preoperative phase (fine-needle aspiration biopsy/core-needle biopsy under ultrasound guidance) allows minimize the number of errors for the regional staging. The sentinel lymph node biopsy (SLNB) is the gold standard of regional treatment in patients with early stage BC, nowadays. The randomized trials (NSABP B-32, ACOSOG q0011) show the safety of recession of performing regional lymph node dissection in favor of SLNB not only in case of clinically negative lymph nodes, but also in patients with metastases in 2 sentinel lymph nodes, upon condition that organ-conservative treatment and subsequent radiation therapy will be used. High-quality regional staging, the choice of the therapeutic algorithm in accordance with the biological characteristics of carcinoma, the application of the most effective modern drug regimes, the optimal radiation therapy allow not only minimize the extent of surgery, but also achieve high long-term survival results, provide excellent functional results and high quality of life in patients with the involvement of axillary lymph nodes.
format	article
author	Irina V. Kolyadina Tatiana Yu. Danzanova Svetlana V. Khokhlova Oksana P. Trofimova Ekaterina V. Kovaleva Valerii V. Rodionov Irina V. Poddubnaya
author_facet	Irina V. Kolyadina Tatiana Yu. Danzanova Svetlana V. Khokhlova Oksana P. Trofimova Ekaterina V. Kovaleva Valerii V. Rodionov Irina V. Poddubnaya
author_sort	Irina V. Kolyadina
title	Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
title_short	Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
title_full	Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
title_fullStr	Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
title_full_unstemmed	Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
title_sort	modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer
publisher	IP Habib O.N.
publishDate	2020
url	https://doaj.org/article/e0d0f965dba7427899ab6e589e1caaa9
work_keys_str_mv	AT irinavkolyadina modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer AT tatianayudanzanova modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer AT svetlanavkhokhlova modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer AT oksanaptrofimova modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer AT ekaterinavkovaleva modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer AT valeriivrodionov modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer AT irinavpoddubnaya modernviewontheissuesofdiagnosisandverificationofaxillarylymphnodesinvolvementinearlybreastcancer
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Modern view on the issues of diagnosis and verification of axillary lymph nodes involvement in early breast cancer

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