Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, functi...

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Autores principales:	Silvana Valdebenito, Shaily Malik, Ross Luu, Olivier Loudig, Megan Mitchell, George Okafo, Krishna Bhat, Brendan Prideaux, Eliseo A. Eugenin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0d2633ce8134bc0b579ada8b11a03c8
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spelling	oai:doaj.org-article:e0d2633ce8134bc0b579ada8b11a03c82021-12-02T18:30:58ZTunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions10.1038/s41598-021-93775-82045-2322https://doaj.org/article/e0d2633ce8134bc0b579ada8b11a03c82021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93775-8https://doaj.org/toc/2045-2322Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor.Silvana ValdebenitoShaily MalikRoss LuuOlivier LoudigMegan MitchellGeorge OkafoKrishna BhatBrendan PrideauxEliseo A. EugeninNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Silvana Valdebenito Shaily Malik Ross Luu Olivier Loudig Megan Mitchell George Okafo Krishna Bhat Brendan Prideaux Eliseo A. Eugenin Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
description	Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor.
format	article
author	Silvana Valdebenito Shaily Malik Ross Luu Olivier Loudig Megan Mitchell George Okafo Krishna Bhat Brendan Prideaux Eliseo A. Eugenin
author_facet	Silvana Valdebenito Shaily Malik Ross Luu Olivier Loudig Megan Mitchell George Okafo Krishna Bhat Brendan Prideaux Eliseo A. Eugenin
author_sort	Silvana Valdebenito
title	Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
title_short	Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
title_full	Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
title_fullStr	Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
title_full_unstemmed	Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
title_sort	tunneling nanotubes, tnt, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0d2633ce8134bc0b579ada8b11a03c8
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Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

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