Loss of the transcription factor MAFB limits β-cell derivation from human PSCs

The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.

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Autores principales:	Ronan Russell, Phichitpol P. Carnese, Thomas G. Hennings, Emily M. Walker, Holger A. Russ, Jennifer S. Liu, Simone Giacometti, Roland Stein, Matthias Hebrok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c
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spelling	oai:doaj.org-article:e0d2c3d6cf86401bb280695fe609017c2021-12-02T18:24:49ZLoss of the transcription factor MAFB limits β-cell derivation from human PSCs10.1038/s41467-020-16550-92041-1723https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16550-9https://doaj.org/toc/2041-1723The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.Ronan RussellPhichitpol P. CarneseThomas G. HenningsEmily M. WalkerHolger A. RussJennifer S. LiuSimone GiacomettiRoland SteinMatthias HebrokNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ronan Russell Phichitpol P. Carnese Thomas G. Hennings Emily M. Walker Holger A. Russ Jennifer S. Liu Simone Giacometti Roland Stein Matthias Hebrok Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
description	The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.
format	article
author	Ronan Russell Phichitpol P. Carnese Thomas G. Hennings Emily M. Walker Holger A. Russ Jennifer S. Liu Simone Giacometti Roland Stein Matthias Hebrok
author_facet	Ronan Russell Phichitpol P. Carnese Thomas G. Hennings Emily M. Walker Holger A. Russ Jennifer S. Liu Simone Giacometti Roland Stein Matthias Hebrok
author_sort	Ronan Russell
title	Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
title_short	Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
title_full	Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
title_fullStr	Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
title_full_unstemmed	Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
title_sort	loss of the transcription factor mafb limits β-cell derivation from human pscs
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c
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Loss of the transcription factor MAFB limits β-cell derivation from human PSCs

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