Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose neurons and enterocytes in a paracrine manner i...

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Autores principales:	Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e965989
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spelling	oai:doaj.org-article:e0d5bffcb836471e9eeb57ed1e9659892021-12-02T14:39:03ZAdenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons10.1038/s41467-019-09045-92041-1723https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e9659892019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09045-9https://doaj.org/toc/2041-1723Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose neurons and enterocytes in a paracrine manner in vitro.Van B. LuJuraj RievajElisabeth A. O’FlahertyChristopher A. SmithRamona PaisLuke A. PattisonGwen TolhurstAndrew B. LeiterDavid C. BulmerFiona M. GribbleFrank ReimannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Van B. Lu Juraj Rievaj Elisabeth A. O’Flaherty Christopher A. Smith Ramona Pais Luke A. Pattison Gwen Tolhurst Andrew B. Leiter David C. Bulmer Fiona M. Gribble Frank Reimann Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
description	Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose neurons and enterocytes in a paracrine manner in vitro.
format	article
author	Van B. Lu Juraj Rievaj Elisabeth A. O’Flaherty Christopher A. Smith Ramona Pais Luke A. Pattison Gwen Tolhurst Andrew B. Leiter David C. Bulmer Fiona M. Gribble Frank Reimann
author_facet	Van B. Lu Juraj Rievaj Elisabeth A. O’Flaherty Christopher A. Smith Ramona Pais Luke A. Pattison Gwen Tolhurst Andrew B. Leiter David C. Bulmer Fiona M. Gribble Frank Reimann
author_sort	Van B. Lu
title	Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
title_short	Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
title_full	Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
title_fullStr	Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
title_full_unstemmed	Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
title_sort	adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e965989
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Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

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