Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient

SARS-CoV-2 isolates from long-term COVID-19 patients play a significant role in understanding the mechanisms of infection and virus persistence. This study describes a SARS-CoV-2 isolate from a 53-year-old woman from Apulia (Italy), who was COVID-19 positive for approximately four months. In this pa...

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Autores principales:	Loredana Capozzi, Domenico Simone, Angelica Bianco, Laura Del Sambro, Valeria Rondinone, Lorenzo Pace, Viviana Manzulli, Michela Iacobellis, Antonio Parisi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 genomic surveillance whole genome sequencing Pangolin lineage genome mutations Science Q
Acceso en línea:	https://doaj.org/article/e0d8299f6f1d420e82c8eab0bfb31d98
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spelling	oai:doaj.org-article:e0d8299f6f1d420e82c8eab0bfb31d982021-11-25T18:11:39ZEmerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient10.3390/life111112592075-1729https://doaj.org/article/e0d8299f6f1d420e82c8eab0bfb31d982021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1259https://doaj.org/toc/2075-1729SARS-CoV-2 isolates from long-term COVID-19 patients play a significant role in understanding the mechanisms of infection and virus persistence. This study describes a SARS-CoV-2 isolate from a 53-year-old woman from Apulia (Italy), who was COVID-19 positive for approximately four months. In this paper we aimed to investigate any potential correlation between genetic mutations and clinical features of this case of infection. The viral isolate was assigned to lineage B.1.177.51 through whole-genome sequencing (WGS) and harbored a novel set of mutations on the Spike protein (V143D, del144/145 and E484K); furthermore, seroneutralization assays showed impaired response of the surveyed strain to BNT162b2 (Comirnaty) Pfizer/BioNTech vaccine-induced (average reduction of 70%) and convalescent sera (average reduction of 19.04%), when compared to VOC P.1. This study highlights the importance of genomic surveillance for the management of the COVID-19 pandemic, the relevance of monitoring of emerging SARS-CoV-2 mutations in all lineages, and the necessity of testing the response of emerging variants to available therapies and vaccines.Loredana CapozziDomenico SimoneAngelica BiancoLaura Del SambroValeria RondinoneLorenzo PaceViviana ManzulliMichela IacobellisAntonio ParisiMDPI AGarticleCOVID-19SARS-CoV-2genomic surveillancewhole genome sequencingPangolin lineagegenome mutationsScienceQENLife, Vol 11, Iss 1259, p 1259 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 genomic surveillance whole genome sequencing Pangolin lineage genome mutations Science Q
spellingShingle	COVID-19 SARS-CoV-2 genomic surveillance whole genome sequencing Pangolin lineage genome mutations Science Q Loredana Capozzi Domenico Simone Angelica Bianco Laura Del Sambro Valeria Rondinone Lorenzo Pace Viviana Manzulli Michela Iacobellis Antonio Parisi Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient
description	SARS-CoV-2 isolates from long-term COVID-19 patients play a significant role in understanding the mechanisms of infection and virus persistence. This study describes a SARS-CoV-2 isolate from a 53-year-old woman from Apulia (Italy), who was COVID-19 positive for approximately four months. In this paper we aimed to investigate any potential correlation between genetic mutations and clinical features of this case of infection. The viral isolate was assigned to lineage B.1.177.51 through whole-genome sequencing (WGS) and harbored a novel set of mutations on the Spike protein (V143D, del144/145 and E484K); furthermore, seroneutralization assays showed impaired response of the surveyed strain to BNT162b2 (Comirnaty) Pfizer/BioNTech vaccine-induced (average reduction of 70%) and convalescent sera (average reduction of 19.04%), when compared to VOC P.1. This study highlights the importance of genomic surveillance for the management of the COVID-19 pandemic, the relevance of monitoring of emerging SARS-CoV-2 mutations in all lineages, and the necessity of testing the response of emerging variants to available therapies and vaccines.
format	article
author	Loredana Capozzi Domenico Simone Angelica Bianco Laura Del Sambro Valeria Rondinone Lorenzo Pace Viviana Manzulli Michela Iacobellis Antonio Parisi
author_facet	Loredana Capozzi Domenico Simone Angelica Bianco Laura Del Sambro Valeria Rondinone Lorenzo Pace Viviana Manzulli Michela Iacobellis Antonio Parisi
author_sort	Loredana Capozzi
title	Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient
title_short	Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient
title_full	Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient
title_fullStr	Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient
title_full_unstemmed	Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient
title_sort	emerging mutations potentially related to sars-cov-2 immune escape: the case of a long-term patient
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0d8299f6f1d420e82c8eab0bfb31d98
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Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient

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