Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy
Uri Soiberman,1,2 Ran Levy,1,2 Igal Leibovitch1,2 1Department of Ophthalmology, Tel Aviv Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose ti...
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Dove Medical Press
2013
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oai:doaj.org-article:e0dac74278cc4bf8978e43848df3e2f22021-12-02T01:14:09ZAdiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy1177-54671177-5483https://doaj.org/article/e0dac74278cc4bf8978e43848df3e2f22013-08-01T00:00:00Zhttp://www.dovepress.com/adiponectin-concentration-in-the-orbital-fat-of-patients-with-graves39-a14160https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Uri Soiberman,1,2 Ran Levy,1,2 Igal Leibovitch1,2 1Department of Ophthalmology, Tel Aviv Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups. Keywords: Graves' disease, Graves' orbitopathy, ELISASoiberman ULevy RLeibovitch IDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1723-1726 (2013) |
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DOAJ |
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DOAJ |
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EN |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Soiberman U Levy R Leibovitch I Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy |
| description |
Uri Soiberman,1,2 Ran Levy,1,2 Igal Leibovitch1,2 1Department of Ophthalmology, Tel Aviv Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups. Keywords: Graves' disease, Graves' orbitopathy, ELISA |
| format |
article |
| author |
Soiberman U Levy R Leibovitch I |
| author_facet |
Soiberman U Levy R Leibovitch I |
| author_sort |
Soiberman U |
| title |
Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy |
| title_short |
Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy |
| title_full |
Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy |
| title_fullStr |
Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy |
| title_full_unstemmed |
Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy |
| title_sort |
adiponectin concentration in the orbital fat of patients with graves' ophthalmopathy |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/e0dac74278cc4bf8978e43848df3e2f2 |
| work_keys_str_mv |
AT soibermanu adiponectinconcentrationintheorbitalfatofpatientswithgraves39ophthalmopathy AT levyr adiponectinconcentrationintheorbitalfatofpatientswithgraves39ophthalmopathy AT leibovitchi adiponectinconcentrationintheorbitalfatofpatientswithgraves39ophthalmopathy |
| _version_ |
1718403228336390144 |