Intraocular infections in the neonatal intensive care unit

Intraocular infections in the neonatal intensive care unit

Hassan A Aziz1, Audina M Berrocal1,2, Robert A Sisk1, Kristin Hartley1, Magaly Diaz-Barbosa2, Rose A Johnson2, Ditte Hess1, Sander R Dubovy1, Timothy G Murray1, Harry W Flynn Jr11Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 2Jackson Memoria...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sisk RA, Berrocal AM, Aziz HA, Flynn Jr HW, Murray TG, Dubovy SR, Hess D, Johnson RA, Hartley K, Diaz-Barbosa M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/e0dc6baa8a7d410c9b5cd7eda9ad4231
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e0dc6baa8a7d410c9b5cd7eda9ad4231
record_format dspace
spelling oai:doaj.org-article:e0dc6baa8a7d410c9b5cd7eda9ad42312021-12-02T07:31:44ZIntraocular infections in the neonatal intensive care unit1177-54671177-5483https://doaj.org/article/e0dc6baa8a7d410c9b5cd7eda9ad42312012-05-01T00:00:00Zhttp://www.dovepress.com/intraocular-infections-in-the-neonatal-intensive-care-unit-a9899https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Hassan A Aziz1, Audina M Berrocal1,2, Robert A Sisk1, Kristin Hartley1, Magaly Diaz-Barbosa2, Rose A Johnson2, Ditte Hess1, Sander R Dubovy1, Timothy G Murray1, Harry W Flynn Jr11Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 2Jackson Memorial Hospital, Miami, FL, USABackground: The purpose of this study was to report on the incidence and treatment outcomes of endogenous endophthalmitis among newborns in the neonatal intensive care unit (NICU) of a single medical center.Methods: This was a noncomparative, retrospective case series of endogenous endophthalmitis among infants at the Jackson Memorial Hospital NICU treated between March 1, 2002 and March 1, 2007.Results: Of 4323 infants admitted to the NICU, seven eyes of six (0.139%) infants (two males, four females) were diagnosed with endophthalmitis during the study period. Four patients were born prematurely with a mean gestational age of 27.5 weeks and a mean birth weight of 1153 g. Retinopathy of prematurity was reported in two of the six patients. Mean follow-up was 3.5 years. The diagnosis was confirmed by positive cultures or polymerase chain reaction testing at a median age of 34 postnatal days. Positive cultures included Candida albicans (n = 4), Pseudomonas aeruginosa (n = 1), and Herpes simplex type 2 (n = 1). All patients received systemic treatment and five received adjunctive ophthalmic interventions, including intravitreal antibiotics in five eyes of four patients and vitrectomy with pars plana lensectomy in three eyes. One patient underwent primary enucleation and another had delayed evisceration. In the remaining five eyes, there was a normal appearing posterior segment and normal intraocular pressures at last follow-up.Conclusion: Endogenous endophthalmitis is a rare complication in infants in the NICU, but may occur in patients with candidemia, bacteremia, retinopathy of prematurity, and low birth weight. Despite early and appropriate treatment, involved eyes may have poor outcomes.Keywords: endogenous endophthalmitis, neonatal intensive care unitSisk RABerrocal AMAziz HAFlynn Jr HWMurray TGDubovy SRHess DJohnson RAHartley KDiaz-Barbosa MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 733-737 (2012)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Sisk RA
Berrocal AM
Aziz HA
Flynn Jr HW
Murray TG
Dubovy SR
Hess D
Johnson RA
Hartley K
Diaz-Barbosa M
Intraocular infections in the neonatal intensive care unit
description Hassan A Aziz1, Audina M Berrocal1,2, Robert A Sisk1, Kristin Hartley1, Magaly Diaz-Barbosa2, Rose A Johnson2, Ditte Hess1, Sander R Dubovy1, Timothy G Murray1, Harry W Flynn Jr11Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 2Jackson Memorial Hospital, Miami, FL, USABackground: The purpose of this study was to report on the incidence and treatment outcomes of endogenous endophthalmitis among newborns in the neonatal intensive care unit (NICU) of a single medical center.Methods: This was a noncomparative, retrospective case series of endogenous endophthalmitis among infants at the Jackson Memorial Hospital NICU treated between March 1, 2002 and March 1, 2007.Results: Of 4323 infants admitted to the NICU, seven eyes of six (0.139%) infants (two males, four females) were diagnosed with endophthalmitis during the study period. Four patients were born prematurely with a mean gestational age of 27.5 weeks and a mean birth weight of 1153 g. Retinopathy of prematurity was reported in two of the six patients. Mean follow-up was 3.5 years. The diagnosis was confirmed by positive cultures or polymerase chain reaction testing at a median age of 34 postnatal days. Positive cultures included Candida albicans (n = 4), Pseudomonas aeruginosa (n = 1), and Herpes simplex type 2 (n = 1). All patients received systemic treatment and five received adjunctive ophthalmic interventions, including intravitreal antibiotics in five eyes of four patients and vitrectomy with pars plana lensectomy in three eyes. One patient underwent primary enucleation and another had delayed evisceration. In the remaining five eyes, there was a normal appearing posterior segment and normal intraocular pressures at last follow-up.Conclusion: Endogenous endophthalmitis is a rare complication in infants in the NICU, but may occur in patients with candidemia, bacteremia, retinopathy of prematurity, and low birth weight. Despite early and appropriate treatment, involved eyes may have poor outcomes.Keywords: endogenous endophthalmitis, neonatal intensive care unit
format article
author Sisk RA
Berrocal AM
Aziz HA
Flynn Jr HW
Murray TG
Dubovy SR
Hess D
Johnson RA
Hartley K
Diaz-Barbosa M
author_facet Sisk RA
Berrocal AM
Aziz HA
Flynn Jr HW
Murray TG
Dubovy SR
Hess D
Johnson RA
Hartley K
Diaz-Barbosa M
author_sort Sisk RA
title Intraocular infections in the neonatal intensive care unit
title_short Intraocular infections in the neonatal intensive care unit
title_full Intraocular infections in the neonatal intensive care unit
title_fullStr Intraocular infections in the neonatal intensive care unit
title_full_unstemmed Intraocular infections in the neonatal intensive care unit
title_sort intraocular infections in the neonatal intensive care unit
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/e0dc6baa8a7d410c9b5cd7eda9ad4231
work_keys_str_mv AT siskra intraocularinfectionsintheneonatalintensivecareunit
AT berrocalam intraocularinfectionsintheneonatalintensivecareunit
AT azizha intraocularinfectionsintheneonatalintensivecareunit
AT flynnjrhw intraocularinfectionsintheneonatalintensivecareunit
AT murraytg intraocularinfectionsintheneonatalintensivecareunit
AT dubovysr intraocularinfectionsintheneonatalintensivecareunit
AT hessd intraocularinfectionsintheneonatalintensivecareunit
AT johnsonra intraocularinfectionsintheneonatalintensivecareunit
AT hartleyk intraocularinfectionsintheneonatalintensivecareunit
AT diazbarbosam intraocularinfectionsintheneonatalintensivecareunit
_version_ 1718399431473102848

Ejemplares similares