Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

Jiang, Guo, Hao et al. investigate the role of the tumour microenvironment in breast cancer stem cell regulation and identify an arteriolar niche in which BCSCs tended to be enriched in human estrogen receptor positive breast cancer. Here, BCSCs are found to interact with arteriolar endothelial cell...

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Autores principales:	Yinan Jiang, Yichen Guo, Jinjin Hao, Rachael Guenter, Justin Lathia, Adam W. Beck, Reagan Hattaway, Douglas Hurst, Qiming Jane Wang, Yehe Liu, Qi Cao, Helen Krontiras, Herbert Chen, Roy Silverstein, Bin Ren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e0dc6ef2f6a941a99c0be68e37975d99
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spelling	oai:doaj.org-article:e0dc6ef2f6a941a99c0be68e37975d992021-12-02T17:44:54ZDevelopment of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling10.1038/s42003-021-02308-62399-3642https://doaj.org/article/e0dc6ef2f6a941a99c0be68e37975d992021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02308-6https://doaj.org/toc/2399-3642Jiang, Guo, Hao et al. investigate the role of the tumour microenvironment in breast cancer stem cell regulation and identify an arteriolar niche in which BCSCs tended to be enriched in human estrogen receptor positive breast cancer. Here, BCSCs are found to interact with arteriolar endothelial cells through LPA/PKD-1 signalling-mediated arteriolar differentiation of ECs and self-renewal of BCSCs.Yinan JiangYichen GuoJinjin HaoRachael GuenterJustin LathiaAdam W. BeckReagan HattawayDouglas HurstQiming Jane WangYehe LiuQi CaoHelen KrontirasHerbert ChenRoy SilversteinBin RenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yinan Jiang Yichen Guo Jinjin Hao Rachael Guenter Justin Lathia Adam W. Beck Reagan Hattaway Douglas Hurst Qiming Jane Wang Yehe Liu Qi Cao Helen Krontiras Herbert Chen Roy Silverstein Bin Ren Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling
description	Jiang, Guo, Hao et al. investigate the role of the tumour microenvironment in breast cancer stem cell regulation and identify an arteriolar niche in which BCSCs tended to be enriched in human estrogen receptor positive breast cancer. Here, BCSCs are found to interact with arteriolar endothelial cells through LPA/PKD-1 signalling-mediated arteriolar differentiation of ECs and self-renewal of BCSCs.
format	article
author	Yinan Jiang Yichen Guo Jinjin Hao Rachael Guenter Justin Lathia Adam W. Beck Reagan Hattaway Douglas Hurst Qiming Jane Wang Yehe Liu Qi Cao Helen Krontiras Herbert Chen Roy Silverstein Bin Ren
author_facet	Yinan Jiang Yichen Guo Jinjin Hao Rachael Guenter Justin Lathia Adam W. Beck Reagan Hattaway Douglas Hurst Qiming Jane Wang Yehe Liu Qi Cao Helen Krontiras Herbert Chen Roy Silverstein Bin Ren
author_sort	Yinan Jiang
title	Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling
title_short	Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling
title_full	Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling
title_fullStr	Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling
title_full_unstemmed	Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling
title_sort	development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase d signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0dc6ef2f6a941a99c0be68e37975d99
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Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

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