Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes

Vascularization for tissue engineering applications has been challenging over the past decades. Numerous efforts have been made to fabricate artificial arteries and veins, while few focused on capillary vascularization. In this paper, core-sheath electrospinning was adopted to fabricate nanoporous m...

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Autores principales:	Yan Chen, George Z. Tan, Yingge Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	core-sheath electrospinning nanoporous microtubes tissue engineering advanced manufacturing Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/e0e13e4a3d9f4e058839d9b30dfa45f0
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spelling	oai:doaj.org-article:e0e13e4a3d9f4e058839d9b30dfa45f02021-11-11T18:42:42ZEffects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes10.3390/polym132136502073-4360https://doaj.org/article/e0e13e4a3d9f4e058839d9b30dfa45f02021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3650https://doaj.org/toc/2073-4360Vascularization for tissue engineering applications has been challenging over the past decades. Numerous efforts have been made to fabricate artificial arteries and veins, while few focused on capillary vascularization. In this paper, core-sheath electrospinning was adopted to fabricate nanoporous microtubes that mimic the native capillaries. The results showed that both solution viscosity and polyethylene oxide (PEO) ratio in polycaprolactone (PCL) sheath solution had significant effects on microtube diameter. Adding PEO into PCL sheath solution is also beneficial to surface pore formation, although the effects of further increasing PEO showed mixed results in different viscosity groups. Our study showed that the high viscosity group with a PCL/PEO ratio of 3:1 resulted in the highest average microtube diameter (2.14 µm) and pore size (250 nm), which mimics the native human capillary size of 1–10 µm. Therefore, our microtubes show high potential in tissue vascularization of engineered scaffolds.Yan ChenGeorge Z. TanYingge ZhouMDPI AGarticlecore-sheath electrospinningnanoporous microtubestissue engineeringadvanced manufacturingOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3650, p 3650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	core-sheath electrospinning nanoporous microtubes tissue engineering advanced manufacturing Organic chemistry QD241-441
spellingShingle	core-sheath electrospinning nanoporous microtubes tissue engineering advanced manufacturing Organic chemistry QD241-441 Yan Chen George Z. Tan Yingge Zhou Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes
description	Vascularization for tissue engineering applications has been challenging over the past decades. Numerous efforts have been made to fabricate artificial arteries and veins, while few focused on capillary vascularization. In this paper, core-sheath electrospinning was adopted to fabricate nanoporous microtubes that mimic the native capillaries. The results showed that both solution viscosity and polyethylene oxide (PEO) ratio in polycaprolactone (PCL) sheath solution had significant effects on microtube diameter. Adding PEO into PCL sheath solution is also beneficial to surface pore formation, although the effects of further increasing PEO showed mixed results in different viscosity groups. Our study showed that the high viscosity group with a PCL/PEO ratio of 3:1 resulted in the highest average microtube diameter (2.14 µm) and pore size (250 nm), which mimics the native human capillary size of 1–10 µm. Therefore, our microtubes show high potential in tissue vascularization of engineered scaffolds.
format	article
author	Yan Chen George Z. Tan Yingge Zhou
author_facet	Yan Chen George Z. Tan Yingge Zhou
author_sort	Yan Chen
title	Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes
title_short	Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes
title_full	Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes
title_fullStr	Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes
title_full_unstemmed	Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes
title_sort	effects of viscosities and solution composition on core-sheath electrospun polycaprolactone(pcl) nanoporous microtubes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0e13e4a3d9f4e058839d9b30dfa45f0
work_keys_str_mv	AT yanchen effectsofviscositiesandsolutioncompositiononcoresheathelectrospunpolycaprolactonepclnanoporousmicrotubes AT georgeztan effectsofviscositiesandsolutioncompositiononcoresheathelectrospunpolycaprolactonepclnanoporousmicrotubes AT yinggezhou effectsofviscositiesandsolutioncompositiononcoresheathelectrospunpolycaprolactonepclnanoporousmicrotubes
_version_	1718431793247420416

Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes

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