Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis

Abstract Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specif...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Deivide Oliveira-de-Souza, Caian L. Vinhaes, María B. Arriaga, Nathella Pavan Kumar, Artur T. L. Queiroz, Kiyoshi F. Fukutani, Subash Babu, Bruno B. Andrade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0e2c449dfca40ad8077ade9272e5bff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e0e2c449dfca40ad8077ade9272e5bff
record_format	dspace
spelling	oai:doaj.org-article:e0e2c449dfca40ad8077ade9272e5bff2021-12-02T15:39:40ZAging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis10.1038/s41598-020-68255-02045-2322https://doaj.org/article/e0e2c449dfca40ad8077ade9272e5bff2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68255-0https://doaj.org/toc/2045-2322Abstract Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specific biomarker profiles related to inflammation and the diverse clinical disease presentations in TB has been extensively studied in adults. However, relatively scarce data on profiling the inflammatory responses in pediatric TB are available. Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adults or children presenting with pulmonary or extrapulmonary disease. We used multidimensional statistical analyses to characterize the impact of age on the overall changes in the systemic inflammation profiles in subpopulation of TB patients. Our findings indicate that TB results in significant increases in molecular perturbation, with the highest values being detected in adult patients. Furthermore, there were unique differences in the biomarker perturbation patterns and the overall degree of inflammation according to disease site and age. Importantly, the molecular degree of perturbation was not influenced by sex. Our results revealed that aging is an important determinant of the differences in quality and magnitude of systemic inflammatory perturbation in distinct clinical forms of TB.Deivide Oliveira-de-SouzaCaian L. VinhaesMaría B. ArriagaNathella Pavan KumarArtur T. L. QueirozKiyoshi F. FukutaniSubash BabuBruno B. AndradeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deivide Oliveira-de-Souza Caian L. Vinhaes María B. Arriaga Nathella Pavan Kumar Artur T. L. Queiroz Kiyoshi F. Fukutani Subash Babu Bruno B. Andrade Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
description	Abstract Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specific biomarker profiles related to inflammation and the diverse clinical disease presentations in TB has been extensively studied in adults. However, relatively scarce data on profiling the inflammatory responses in pediatric TB are available. Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adults or children presenting with pulmonary or extrapulmonary disease. We used multidimensional statistical analyses to characterize the impact of age on the overall changes in the systemic inflammation profiles in subpopulation of TB patients. Our findings indicate that TB results in significant increases in molecular perturbation, with the highest values being detected in adult patients. Furthermore, there were unique differences in the biomarker perturbation patterns and the overall degree of inflammation according to disease site and age. Importantly, the molecular degree of perturbation was not influenced by sex. Our results revealed that aging is an important determinant of the differences in quality and magnitude of systemic inflammatory perturbation in distinct clinical forms of TB.
format	article
author	Deivide Oliveira-de-Souza Caian L. Vinhaes María B. Arriaga Nathella Pavan Kumar Artur T. L. Queiroz Kiyoshi F. Fukutani Subash Babu Bruno B. Andrade
author_facet	Deivide Oliveira-de-Souza Caian L. Vinhaes María B. Arriaga Nathella Pavan Kumar Artur T. L. Queiroz Kiyoshi F. Fukutani Subash Babu Bruno B. Andrade
author_sort	Deivide Oliveira-de-Souza
title	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
title_short	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
title_full	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
title_fullStr	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
title_full_unstemmed	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
title_sort	aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e0e2c449dfca40ad8077ade9272e5bff
work_keys_str_mv	AT deivideoliveiradesouza agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT caianlvinhaes agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT mariabarriaga agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT nathellapavankumar agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT arturtlqueiroz agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT kiyoshiffukutani agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT subashbabu agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis AT brunobandrade agingincreasesthesystemicmoleculardegreeofinflammatoryperturbationinpatientswithtuberculosis
_version_	1718385904847945728

Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis

Ejemplares similares