Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine

Foot and mouth disease (FMD) is one of the most important viral diseases in Egypt and the main way for its control is sufficient vaccination. A vaccine that could improve early and long-lasting immunity by selecting the best adjuvants is the main target for veterinarians. In this study, different fo...

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Auteurs principaux:	Mohamed A. Gamil, Eman M. Soliman
Format:	article
Langue:	EN
Publié:	Egyptian Society for Animal Management 2021
Sujets:	adjuvants fmd montanide isa206 vegetable oils Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Accès en ligne:	https://dx.doi.org/10.21608/javs.2021.154580 https://doaj.org/article/e0e2e65b6069474886d5e73556a331b3
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spelling	oai:doaj.org-article:e0e2e65b6069474886d5e73556a331b32021-12-02T15:51:21ZEffect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccinehttps://dx.doi.org/10.21608/javs.2021.1545801687-40722090-3308https://doaj.org/article/e0e2e65b6069474886d5e73556a331b32021-04-01T00:00:00Zhttps://javs.journals.ekb.eg/article_154580.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308Foot and mouth disease (FMD) is one of the most important viral diseases in Egypt and the main way for its control is sufficient vaccination. A vaccine that could improve early and long-lasting immunity by selecting the best adjuvants is the main target for veterinarians. In this study, different formulae from polyvalent inactivated FMD vaccine were prepared using different vegetable oils (Peanut oil, Olive oil, and Sunflower oil) supplemented with Ginseng saponin and compared with locally used Montanide ISA206 as alternative adjuvants. Evaluation of such formulae was carried out through the international quality control protocol for vaccine evaluation, vaccination of calves groups to follow up their cell-mediated immunity using lymphocytic proliferation assay and level determination of interleukine-6, interleukin12 by the fourth week post-vaccination. Humeral immune response was evaluated by recording serum neutralizing antibodies' protective values by the 6th week. All the prepared vaccine formulae were found to be potent for vaccinated calves, except the Olive oil vaccine showed week performance. Our data suggest that Peanut oil and Sunflower oil supplemented with Ginseng saponin could be used as adjuvants in polyvalent FMD vaccine with comparable results to conventionally used mineral oil Montanide ISA206.Mohamed A. GamilEman M. SolimanEgyptian Society for Animal Managementarticleadjuvantsfmdmontanide isa206vegetable oilsZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 6, Iss 2, Pp 37-43 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adjuvants fmd montanide isa206 vegetable oils Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	adjuvants fmd montanide isa206 vegetable oils Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Mohamed A. Gamil Eman M. Soliman Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine
description	Foot and mouth disease (FMD) is one of the most important viral diseases in Egypt and the main way for its control is sufficient vaccination. A vaccine that could improve early and long-lasting immunity by selecting the best adjuvants is the main target for veterinarians. In this study, different formulae from polyvalent inactivated FMD vaccine were prepared using different vegetable oils (Peanut oil, Olive oil, and Sunflower oil) supplemented with Ginseng saponin and compared with locally used Montanide ISA206 as alternative adjuvants. Evaluation of such formulae was carried out through the international quality control protocol for vaccine evaluation, vaccination of calves groups to follow up their cell-mediated immunity using lymphocytic proliferation assay and level determination of interleukine-6, interleukin12 by the fourth week post-vaccination. Humeral immune response was evaluated by recording serum neutralizing antibodies' protective values by the 6th week. All the prepared vaccine formulae were found to be potent for vaccinated calves, except the Olive oil vaccine showed week performance. Our data suggest that Peanut oil and Sunflower oil supplemented with Ginseng saponin could be used as adjuvants in polyvalent FMD vaccine with comparable results to conventionally used mineral oil Montanide ISA206.
format	article
author	Mohamed A. Gamil Eman M. Soliman
author_facet	Mohamed A. Gamil Eman M. Soliman
author_sort	Mohamed A. Gamil
title	Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine
title_short	Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine
title_full	Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine
title_fullStr	Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine
title_full_unstemmed	Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine
title_sort	effect of vegetable oils as adjuvants on immune response to polyvalent foot and mouth disease inactivated vaccine
publisher	Egyptian Society for Animal Management
publishDate	2021
url	https://dx.doi.org/10.21608/javs.2021.154580 https://doaj.org/article/e0e2e65b6069474886d5e73556a331b3
work_keys_str_mv	AT mohamedagamil effectofvegetableoilsasadjuvantsonimmuneresponsetopolyvalentfootandmouthdiseaseinactivatedvaccine AT emanmsoliman effectofvegetableoilsasadjuvantsonimmuneresponsetopolyvalentfootandmouthdiseaseinactivatedvaccine
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Effect of Vegetable Oils as Adjuvants on Immune Response to Polyvalent Foot and Mouth Disease Inactivated Vaccine

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