A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients
Since its first detection in December 2019, more than 232 million cases of COVID-19, including 4.7 million deaths, have been reported by the WHO. The SARS-CoV-2 viral genomes have evolved rapidly worldwide, causing the emergence of new variants. This systematic review and meta-analysis was conducted...
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2021
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oai:doaj.org-article:e0e4512abf424cf5866f0115cf49bf8d2021-11-25T18:11:20ZA Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients10.3390/life111112242075-1729https://doaj.org/article/e0e4512abf424cf5866f0115cf49bf8d2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1224https://doaj.org/toc/2075-1729Since its first detection in December 2019, more than 232 million cases of COVID-19, including 4.7 million deaths, have been reported by the WHO. The SARS-CoV-2 viral genomes have evolved rapidly worldwide, causing the emergence of new variants. This systematic review and meta-analysis was conducted to provide a global mutational profile of SARS-CoV-2 from December 2019 to October 2020. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA), and a study protocol was lodged with PROSPERO. Data from 62 eligible studies involving 368,316 SARS-CoV-2 genomes were analyzed. The mutational data analyzed showed most studies detected mutations in the Spike protein (<i>n</i> = 50), Nucleocapsid phosphoprotein (<i>n</i> = 34), ORF1ab gene (<i>n</i> = 29), 5′-UTR (<i>n</i> = 28) and ORF3a (<i>n</i> = 25). Under the random-effects model, pooled prevalence of SARS-CoV-2 variants was estimated at 95.1% (95% CI; 93.3–96.4%; <i>I</i><sup>2</sup> = 98.952%; <i>p</i> = 0.000) while subgroup meta-analysis by country showed majority of the studies were conducted ‘Worldwide’ (<i>n</i> = 10), followed by ‘Multiple countries’ (<i>n</i> = 6) and the USA (<i>n</i> = 5). The estimated prevalence indicated a need to continuously monitor the prevalence of new mutations due to their potential influence on disease severity, transmissibility and vaccine effectiveness.Wardah YusofAhmad Adebayo IrekeolaYusuf WadaEngku Nur Syafirah Engku Abd RahmanNaveed AhmedNurfadhlina MusaMuhammad Fazli KhalidZaidah Abdul RahmanRosline HassanNik Yusnoraini YusofChan Yean YeanMDPI AGarticleCOVID-19SARS-CoV-2mutationmutational profileScienceQENLife, Vol 11, Iss 1224, p 1224 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 SARS-CoV-2 mutation mutational profile Science Q |
| spellingShingle |
COVID-19 SARS-CoV-2 mutation mutational profile Science Q Wardah Yusof Ahmad Adebayo Irekeola Yusuf Wada Engku Nur Syafirah Engku Abd Rahman Naveed Ahmed Nurfadhlina Musa Muhammad Fazli Khalid Zaidah Abdul Rahman Rosline Hassan Nik Yusnoraini Yusof Chan Yean Yean A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients |
| description |
Since its first detection in December 2019, more than 232 million cases of COVID-19, including 4.7 million deaths, have been reported by the WHO. The SARS-CoV-2 viral genomes have evolved rapidly worldwide, causing the emergence of new variants. This systematic review and meta-analysis was conducted to provide a global mutational profile of SARS-CoV-2 from December 2019 to October 2020. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA), and a study protocol was lodged with PROSPERO. Data from 62 eligible studies involving 368,316 SARS-CoV-2 genomes were analyzed. The mutational data analyzed showed most studies detected mutations in the Spike protein (<i>n</i> = 50), Nucleocapsid phosphoprotein (<i>n</i> = 34), ORF1ab gene (<i>n</i> = 29), 5′-UTR (<i>n</i> = 28) and ORF3a (<i>n</i> = 25). Under the random-effects model, pooled prevalence of SARS-CoV-2 variants was estimated at 95.1% (95% CI; 93.3–96.4%; <i>I</i><sup>2</sup> = 98.952%; <i>p</i> = 0.000) while subgroup meta-analysis by country showed majority of the studies were conducted ‘Worldwide’ (<i>n</i> = 10), followed by ‘Multiple countries’ (<i>n</i> = 6) and the USA (<i>n</i> = 5). The estimated prevalence indicated a need to continuously monitor the prevalence of new mutations due to their potential influence on disease severity, transmissibility and vaccine effectiveness. |
| format |
article |
| author |
Wardah Yusof Ahmad Adebayo Irekeola Yusuf Wada Engku Nur Syafirah Engku Abd Rahman Naveed Ahmed Nurfadhlina Musa Muhammad Fazli Khalid Zaidah Abdul Rahman Rosline Hassan Nik Yusnoraini Yusof Chan Yean Yean |
| author_facet |
Wardah Yusof Ahmad Adebayo Irekeola Yusuf Wada Engku Nur Syafirah Engku Abd Rahman Naveed Ahmed Nurfadhlina Musa Muhammad Fazli Khalid Zaidah Abdul Rahman Rosline Hassan Nik Yusnoraini Yusof Chan Yean Yean |
| author_sort |
Wardah Yusof |
| title |
A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients |
| title_short |
A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients |
| title_full |
A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients |
| title_fullStr |
A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients |
| title_full_unstemmed |
A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients |
| title_sort |
global mutational profile of sars-cov-2: a systematic review and meta-analysis of 368,316 covid-19 patients |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/e0e4512abf424cf5866f0115cf49bf8d |
| work_keys_str_mv |
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