Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.

It is widely recognized that propagation of electrophysiological signals between the soma and dendrites of neurons differs depending on direction, i.e. it is asymmetric. How this asymmetry influences the activation of voltage-gated dendritic channels, and consequent neuronal behavior, remains unclea...

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Autores principales:	Hojeong Kim, Kelvin E Jones, C J Heckman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0e87ddbdee9402e9c2df79f1e455dd7
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spelling	oai:doaj.org-article:e0e87ddbdee9402e9c2df79f1e455dd72021-11-25T06:06:25ZAsymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.1932-620310.1371/journal.pone.0095454https://doaj.org/article/e0e87ddbdee9402e9c2df79f1e455dd72014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25083794/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203It is widely recognized that propagation of electrophysiological signals between the soma and dendrites of neurons differs depending on direction, i.e. it is asymmetric. How this asymmetry influences the activation of voltage-gated dendritic channels, and consequent neuronal behavior, remains unclear. Based on the analysis of asymmetry in several types of motoneurons, we extended our previous methodology for reducing a fully reconstructed motoneuron model to a two-compartment representation that preserved asymmetric signal propagation. The reduced models accurately replicated the dendritic excitability and the dynamics of the anatomical model involving a persistent inward current (PIC) dispersed over the dendrites. The relationship between asymmetric signal propagation and dendritic excitability was investigated using the reduced models while varying the asymmetry in signal propagation between the soma and the dendrite with PIC density constant. We found that increases in signal attenuation from soma to dendrites increased the activation threshold of a PIC (hypo-excitability), whereas increases in signal attenuation from dendrites to soma decreased the activation threshold of a PIC (hyper-excitability). These effects were so strong that reversing the asymmetry in the soma-to-dendrite vs. dendrite-to-soma attenuation, reversed the correlation between PIC threshold and distance of this current source from the soma. We propose the tight relation of the asymmetric signal propagation to the input resistance in the dendrites as a mechanism underlying the influence of the asymmetric signal propagation on the dendritic excitability. All these results emphasize the importance of maintaining the physiological asymmetry in dendritic signaling not only for normal function of the cells but also for biophysically realistic simulations of dendritic excitability.Hojeong KimKelvin E JonesC J HeckmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e95454 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hojeong Kim Kelvin E Jones C J Heckman Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
description	It is widely recognized that propagation of electrophysiological signals between the soma and dendrites of neurons differs depending on direction, i.e. it is asymmetric. How this asymmetry influences the activation of voltage-gated dendritic channels, and consequent neuronal behavior, remains unclear. Based on the analysis of asymmetry in several types of motoneurons, we extended our previous methodology for reducing a fully reconstructed motoneuron model to a two-compartment representation that preserved asymmetric signal propagation. The reduced models accurately replicated the dendritic excitability and the dynamics of the anatomical model involving a persistent inward current (PIC) dispersed over the dendrites. The relationship between asymmetric signal propagation and dendritic excitability was investigated using the reduced models while varying the asymmetry in signal propagation between the soma and the dendrite with PIC density constant. We found that increases in signal attenuation from soma to dendrites increased the activation threshold of a PIC (hypo-excitability), whereas increases in signal attenuation from dendrites to soma decreased the activation threshold of a PIC (hyper-excitability). These effects were so strong that reversing the asymmetry in the soma-to-dendrite vs. dendrite-to-soma attenuation, reversed the correlation between PIC threshold and distance of this current source from the soma. We propose the tight relation of the asymmetric signal propagation to the input resistance in the dendrites as a mechanism underlying the influence of the asymmetric signal propagation on the dendritic excitability. All these results emphasize the importance of maintaining the physiological asymmetry in dendritic signaling not only for normal function of the cells but also for biophysically realistic simulations of dendritic excitability.
format	article
author	Hojeong Kim Kelvin E Jones C J Heckman
author_facet	Hojeong Kim Kelvin E Jones C J Heckman
author_sort	Hojeong Kim
title	Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
title_short	Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
title_full	Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
title_fullStr	Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
title_full_unstemmed	Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
title_sort	asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e0e87ddbdee9402e9c2df79f1e455dd7
work_keys_str_mv	AT hojeongkim asymmetryinsignalpropagationbetweenthesomaanddendritesplaysakeyroleindeterminingdendriticexcitabilityinmotoneurons AT kelvinejones asymmetryinsignalpropagationbetweenthesomaanddendritesplaysakeyroleindeterminingdendriticexcitabilityinmotoneurons AT cjheckman asymmetryinsignalpropagationbetweenthesomaanddendritesplaysakeyroleindeterminingdendriticexcitabilityinmotoneurons
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Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.

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