Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essential roles in cancer cell survival and proliferatio...

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Autores principales:	Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef7
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spelling	oai:doaj.org-article:e0ea73c88dab4e7c804e408236956ef72021-12-02T16:43:46ZCopper bioavailability is a KRAS-specific vulnerability in colorectal cancer10.1038/s41467-020-17549-y2041-1723https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17549-yhttps://doaj.org/toc/2041-1723The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essential roles in cancer cell survival and proliferation.Léo AubertNeethi NandagopalZachary SteinhartGeneviève LavoieSami NourreddineJacob BermanMarc K. Saba-El-LeilDavid PapadopoliSichun LinTraver HartGraham MacleodIvan TopisirovicLouis GabouryChristoph J. FahrniDaniel SchramekSylvain MelocheStephane AngersPhilippe P. RouxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Léo Aubert Neethi Nandagopal Zachary Steinhart Geneviève Lavoie Sami Nourreddine Jacob Berman Marc K. Saba-El-Leil David Papadopoli Sichun Lin Traver Hart Graham Macleod Ivan Topisirovic Louis Gaboury Christoph J. Fahrni Daniel Schramek Sylvain Meloche Stephane Angers Philippe P. Roux Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
description	The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essential roles in cancer cell survival and proliferation.
format	article
author	Léo Aubert Neethi Nandagopal Zachary Steinhart Geneviève Lavoie Sami Nourreddine Jacob Berman Marc K. Saba-El-Leil David Papadopoli Sichun Lin Traver Hart Graham Macleod Ivan Topisirovic Louis Gaboury Christoph J. Fahrni Daniel Schramek Sylvain Meloche Stephane Angers Philippe P. Roux
author_facet	Léo Aubert Neethi Nandagopal Zachary Steinhart Geneviève Lavoie Sami Nourreddine Jacob Berman Marc K. Saba-El-Leil David Papadopoli Sichun Lin Traver Hart Graham Macleod Ivan Topisirovic Louis Gaboury Christoph J. Fahrni Daniel Schramek Sylvain Meloche Stephane Angers Philippe P. Roux
author_sort	Léo Aubert
title	Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
title_short	Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
title_full	Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
title_fullStr	Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
title_full_unstemmed	Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
title_sort	copper bioavailability is a kras-specific vulnerability in colorectal cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef7
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Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

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